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dc.contributor.authorKosik-Koziol, Alicja
dc.contributor.authorGraham, Elizabeth
dc.contributor.authorJaroszewicz, Jakub
dc.contributor.authorChlanda, Adrian
dc.contributor.authorKumar, PT Sudheesh
dc.contributor.authorIvanovski, Saso
dc.contributor.authorSwieszkowski, Wojciech
dc.contributor.authorVaquette, Cedryck
dc.date.accessioned2019-10-17T00:24:12Z
dc.date.available2019-10-17T00:24:12Z
dc.date.issued2019
dc.identifier.issn2373-9878en_US
dc.identifier.doi10.1021/acsbiomaterials.8b01018en_US
dc.identifier.urihttp://hdl.handle.net/10072/388457
dc.description.abstractOne promising strategy to reconstruct bone defects relies on 3D printed porous structures. In spite of several studies having been carried out to fabricate controlled, interconnected porous constructs, the control over surface features at, or below, the microscopic scale remains elusive for 3D polymeric scaffolds. In this study, we developed and refined a methodology which can be applied to homogeneously and reproducibly modify the surface of polymeric 3D printed scaffolds. We have demonstrated that the combination of a polymer solvent and the utilization of ultrasound was essential for achieving appropriate surface modification without damaging the structural integrity of the construct. The modification created on the scaffold profoundly affected the macroscopic and microscopic properties of the scaffold with an increased roughness, greater surface area, and reduced hydrophobicity. Furthermore, to assess the performance of such materials in bone tissue engineering, human mesenchymal stem cells (hMSC) were cultured in vitro on the scaffolds for up to 7 days. Our results demonstrate a stronger commitment toward early osteogenic differentiation of hMSC. Finally, we demonstrated that the increased in the specific surface area of the scaffold did not necessarily correlate with improved adsorption of protein and that other factors, such as surface chemistry and hydrophilicity, may also play a major role.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherAmerican Chemical Society (ACS Publications)en_US
dc.relation.ispartofpagefrom318en_US
dc.relation.ispartofpageto328en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalACS Biomaterials Science & Engineeringen_US
dc.relation.ispartofvolume5en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsTechnologyen_US
dc.subject.keywordsMaterials Science, Biomaterialsen_US
dc.subject.keywordssurface modificationen_US
dc.titleSurface Modification of 3D Printed Polycaprolactone Constructs via a Solvent Treatment: Impact on Physical and Osteogenic Propertiesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationKosik-Koziol, A; Graham, E; Jaroszewicz, J; Chlanda, A; Kumar, PTS; Ivanovski, S; Swieszkowski, W; Vaquette, C, Surface Modification of 3D Printed Polycaprolactone Constructs via a Solvent Treatment: Impact on Physical and Osteogenic Properties, ACS Biomaterials Science & Engineering , 2019, 5 (1), pp. 318-328en_US
dc.date.updated2019-10-17T00:22:41Z
gro.hasfulltextNo Full Text
gro.griffith.authorVaquette, Cedryck
gro.griffith.authorIvanovski, Saso


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