Plasmodium falciparum In Vitro Culture - The Highs and Lows
Abstract
Branco et al. [1] raise the following questions. Is there a ‘normal’ oxygen (O2) concentration for in vitro culture of Plasmodium? Would Plasmodium falciparum (Pf) experience such low levels of O2 in an infection, and most importantly, what are the actual O2 conditions in vivo and how best can we mimic these conditions in vitro? All of which are valid and highly relevant questions further highlighting the complexity of the subject and its significance.Branco et al. [1] raise the following questions. Is there a ‘normal’ oxygen (O2) concentration for in vitro culture of Plasmodium? Would Plasmodium falciparum (Pf) experience such low levels of O2 in an infection, and most importantly, what are the actual O2 conditions in vivo and how best can we mimic these conditions in vitro? All of which are valid and highly relevant questions further highlighting the complexity of the subject and its significance.
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Journal Title
Trends in Parasitology
Volume
34
Issue
10
Subject
Biological sciences
Agricultural, veterinary and food sciences
Biomedical and clinical sciences
Veterinary sciences
Medical microbiology
Science & Technology
Life Sciences & Biomedicine
Parasitology
Plasmodium falciparum
in vitro culture