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dc.contributor.authorChan, S
dc.contributor.authorIsbel, NM
dc.contributor.authorHawley, CM
dc.contributor.authorCampbell, SB
dc.contributor.authorCampbell, KL
dc.contributor.authorMorrison, M
dc.contributor.authorFrancis, RS
dc.contributor.authorPlayford, EG
dc.contributor.authorJohnson, DW
dc.date.accessioned2019-10-18T00:27:23Z
dc.date.available2019-10-18T00:27:23Z
dc.date.issued2019
dc.identifier.issn1010-660X
dc.identifier.doi10.3390/medicina55100672
dc.identifier.urihttp://hdl.handle.net/10072/388514
dc.description.abstractThe incidence of infectious complications, compared with the general population and the pre-transplant status of the recipient, increases substantially following kidney transplantation, causing significant morbidity and mortality. The potent immunosuppressive therapy given to prevent graft rejection in kidney transplant recipients results in an increased susceptibility to a wide range of opportunistic infections including bacterial, viral and fungal infections. Over the last five years, several advances have occurred that may have changed the burden of infectious complications in kidney transplant recipients. Due to the availability of direct-acting antivirals to manage donor-derived hepatitis C infection, this has opened the way for donors with hepatitis C infection to be considered in the donation process. In addition, there have been the development of medications targeting the growing burden of resistant cytomegalovirus, as well as the discovery of the potentially important role of the gastrointestinal microbiota in the pathogenesis of post-transplant infection. In this narrative review, we will discuss these three advances and their potential implications for clinical practice.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherKaunas University of Medicine
dc.publisher.placeLithuania
dc.relation.ispartofpagefrom672: 1
dc.relation.ispartofpageto672: 17
dc.relation.ispartofissue10
dc.relation.ispartofjournalMedicina
dc.relation.ispartofvolume55
dc.subject.fieldofresearchGastroenterology and Hepatology
dc.subject.fieldofresearchcode110307
dc.subject.keywordscytomegalovirus
dc.subject.keywordsdirect acting antivirals
dc.subject.keywordsdonor-derived infections
dc.subject.keywordsgastrointestinal microbiome
dc.subject.keywordshepatitis C
dc.titleInfectious Complications Following Kidney Transplantation-A Focus on Hepatitis C Infection, Cytomegalovirus Infection and Novel Developments in the Gut Microbiota
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationChan, S; Isbel, NM; Hawley, CM; Campbell, SB; Campbell, KL; Morrison, M; Francis, RS; Playford, EG; Johnson, DW, Infectious Complications Following Kidney Transplantation-A Focus on Hepatitis C Infection, Cytomegalovirus Infection and Novel Developments in the Gut Microbiota, Medicina, 2019, 55 (10), pp. 672: 1-672: 17
dcterms.dateAccepted2019-09-30
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-10-18T00:08:36Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
gro.hasfulltextFull Text
gro.griffith.authorCampbell, Katrina
gro.griffith.authorPlayford, Elliott G.


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