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dc.contributor.authorEdson, D
dc.contributor.authorPeel, AJ
dc.contributor.authorHuth, L
dc.contributor.authorMayer, DG
dc.contributor.authorVidgen, ME
dc.contributor.authorMcMichael, L
dc.contributor.authorBroos, A
dc.contributor.authorMelville, D
dc.contributor.authorKristoffersen, J
dc.contributor.authorde Jong, C
dc.contributor.authorMcLaughlin, A
dc.contributor.authorField, HE
dc.date.accessioned2019-10-18T03:52:55Z
dc.date.available2019-10-18T03:52:55Z
dc.date.issued2019
dc.identifier.issn0950-2688en_US
dc.identifier.doi10.1017/S0950268819001237en_US
dc.identifier.urihttp://hdl.handle.net/10072/388533
dc.description.abstractHendra virus (HeV) continues to cause fatal infection in horses and threaten infection in close-contact humans in eastern Australia. Species of Pteropus bats (flying-foxes) are the natural reservoir of the virus. We caught and sampled flying-foxes from a multispecies roost in southeast Queensland, Australia on eight occasions between June 2013 and June 2014. The effects of sample date, species, sex, age class, body condition score (BCS), pregnancy and lactation on HeV antibody prevalence, log-transformed median fluorescent intensity (lnMFI) values and HeV RNA status were assessed using unbalanced generalised linear models. A total of 1968 flying-foxes were sampled, comprising 1012 Pteropus alecto, 742 P. poliocephalus and 214 P. scapulatus. Sample date, species and age class were each statistically associated with HeV RNA status, antibody status and lnMFI values; BCS was statistically associated with HeV RNA status and antibody status. The findings support immunologically naïve sub-adult P. alecto playing an important role in maintaining HeV infection at a population level. The biological significance of the association between BCS and HeV RNA status, and BCS and HeV antibody status, is less clear and warrants further investigation. Contrary to previous studies, we found no direct association between HeV infection and pregnancy or lactation. The findings in P. poliocephalus suggest that HeV exposure in this species may not result in systemic infection and virus excretion, or alternatively, may reflect assay cross-reactivity with another (unidentified) henipavirus.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherCambridge University Pressen_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto10en_US
dc.relation.ispartofjournalEpidemiology and Infectionen_US
dc.relation.ispartofvolume147en_US
dc.subject.fieldofresearchPublic Health and Health Servicesen_US
dc.subject.fieldofresearchcode1117en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsPublic, Environmental & Occupational Healthen_US
dc.subject.keywordsInfectious Diseasesen_US
dc.subject.keywordsEmerging infectionsen_US
dc.titleTime of year, age class and body condition predict Hendra virus infection in Australian black flying foxes (Pteropus alecto)en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationEdson, D; Peel, AJ; Huth, L; Mayer, DG; Vidgen, ME; McMichael, L; Broos, A; Melville, D; Kristoffersen, J; de Jong, C; McLaughlin, A; Field, HE, Time of year, age class and body condition predict Hendra virus infection in Australian black flying foxes (Pteropus alecto), Epidemiology and Infection, 2019, 147, pp. 1-10en_US
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2019-10-18T03:49:05Z
dc.description.versionPublisheden_US
gro.rights.copyright© The Author(s) 2019. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence, which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorPeel, Alison J.


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