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  • Proteomic approaches unravel the intricacy of secreted proteins of Leishmania: An updated review

    Author(s)
    Garg, G
    Singh, K
    Ali, V
    Griffith University Author(s)
    Singh, Kuljit
    Year published
    2018
    Metadata
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    Abstract
    Leishmaniasis, a parasitic protozoan disease, is still a worldwide concern due to persistent issues with chemotherapy, rapid emerging drug resistance; and non- availability of approved vaccine for the control of disease. Therefore, the search of parasite specific proteins to identify new anti-leishmanial drug targets and vaccine candidates is an urgent priority. In this context, proteins that are secreted, in vitro during parasite growth under defined conditions, can be explored as potential tool for studying their roles in parasite survival inside host and disease pathogenesis. From the last few years, various approaches ...
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    Leishmaniasis, a parasitic protozoan disease, is still a worldwide concern due to persistent issues with chemotherapy, rapid emerging drug resistance; and non- availability of approved vaccine for the control of disease. Therefore, the search of parasite specific proteins to identify new anti-leishmanial drug targets and vaccine candidates is an urgent priority. In this context, proteins that are secreted, in vitro during parasite growth under defined conditions, can be explored as potential tool for studying their roles in parasite survival inside host and disease pathogenesis. From the last few years, various approaches have been exploited to identify the proteins secreted out by the parasites under defined conditions at particular stage or time. Due to availability of genomic information on various Leishmania species, proteomics have been emerged as most promising approach for analyzing the complexity of exoproteome of different Leishmania species. Herein, we have summarized various secretion mechanisms used by Leishmania parasites to export the proteins into the extracellular space; followed by the role of proteomics in exoproteome analysis along with special emphasis on various applications to study the exoproteome, which might provide potential targets for drug design or novel antigens for vaccine development.
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    Journal Title
    Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
    Volume
    1866
    Issue
    8
    DOI
    https://doi.org/10.1016/j.bbapap.2018.05.011
    Subject
    Biological sciences
    Diagnosis
    Exoproteome
    Immune modulation
    Proteomics
    Vaccine candidate
    Publication URI
    http://hdl.handle.net/10072/388548
    Collection
    • Journal articles

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