Show simple item record

dc.contributor.authorGarg, G
dc.contributor.authorSingh, K
dc.contributor.authorAli, V
dc.date.accessioned2019-10-21T01:34:14Z
dc.date.available2019-10-21T01:34:14Z
dc.date.issued2018
dc.identifier.issn1570-9639
dc.identifier.doi10.1016/j.bbapap.2018.05.011
dc.identifier.urihttp://hdl.handle.net/10072/388548
dc.description.abstractLeishmaniasis, a parasitic protozoan disease, is still a worldwide concern due to persistent issues with chemotherapy, rapid emerging drug resistance; and non- availability of approved vaccine for the control of disease. Therefore, the search of parasite specific proteins to identify new anti-leishmanial drug targets and vaccine candidates is an urgent priority. In this context, proteins that are secreted, in vitro during parasite growth under defined conditions, can be explored as potential tool for studying their roles in parasite survival inside host and disease pathogenesis. From the last few years, various approaches have been exploited to identify the proteins secreted out by the parasites under defined conditions at particular stage or time. Due to availability of genomic information on various Leishmania species, proteomics have been emerged as most promising approach for analyzing the complexity of exoproteome of different Leishmania species. Herein, we have summarized various secretion mechanisms used by Leishmania parasites to export the proteins into the extracellular space; followed by the role of proteomics in exoproteome analysis along with special emphasis on various applications to study the exoproteome, which might provide potential targets for drug design or novel antigens for vaccine development.
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom913
dc.relation.ispartofpageto923
dc.relation.ispartofissue8
dc.relation.ispartofjournalBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics
dc.relation.ispartofvolume1866
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchcode31
dc.subject.keywordsDiagnosis
dc.subject.keywordsExoproteome
dc.subject.keywordsImmune modulation
dc.subject.keywordsProteomics
dc.subject.keywordsVaccine candidate
dc.titleProteomic approaches unravel the intricacy of secreted proteins of Leishmania: An updated review
dc.typeJournal article
dcterms.bibliographicCitationGarg, G; Singh, K; Ali, V, Proteomic approaches unravel the intricacy of secreted proteins of Leishmania: An updated review, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2018, 1866 (8), pp. 913-923
dcterms.dateAccepted2018-05-22
dc.date.updated2019-10-21T01:31:48Z
gro.hasfulltextNo Full Text
gro.griffith.authorSingh, Kuljit


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record