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dc.contributor.authorSarhadinejad, Zohreh
dc.contributor.authorTajadini, Haleh
dc.contributor.authorTansaz, Mojgan
dc.contributor.authorBahrampour, Abbas
dc.contributor.authorSarhadynejad, Zarrin
dc.contributor.authorAnsari, Mehdi
dc.contributor.authorSharififar, Fariba
dc.contributor.authorIranpour, Maryam
dc.contributor.authorSalari, Zohreh
dc.date.accessioned2019-10-21T03:46:39Z
dc.date.available2019-10-21T03:46:39Z
dc.date.issued2018
dc.identifier.issn2074-1804
dc.identifier.doi10.5812/ircmj.74211
dc.identifier.urihttp://hdl.handle.net/10072/388563
dc.description.abstractBackground: Vulvovaginal candidiasis (VVC) is a very common debility in gynecology clinics. Despite access to several antifungal agents, VVC is still a challenge; therefore, presenting a novel antifungal agent, especially with a traditional origin, is of interest and demand. Objectives: The current study aimed at comparing the efficacy of Anethum graveolens L. (dill) vaginal cream with that of 1% Clotrimazole vaginal cream to treat VVC. Methods: A prospective, single-center, randomized, double-blind clinical trial was performed. In the current study, married females aged 18-65 years, with probable vulvovaginal candidiasis were enrolled for primary evaluation. After VVC confirmation by the sniff test, the patients were allocated into three groups with regard to blocked randomization, and inclusion and exclusion criteria. The first group (n = 59) was treated with 1% Clotrimazole vaginal cream; the second (n = 60) with a combination of dill seed essential oil and dried aqueous extract vaginal cream (TEE); and the last (n = 56) with dill seed essential oil vaginal cream (EO) for seven nights. After 10 days, the therapeutic effects were assessed. Results: After the intervention, itching decreased to 30.5%, 3.3%, and 12.5% in the Clotrimazole, TEE, and EO groups, respectively; the sniff test also decreased to 33.9%, 13.3%, and 12.5%, respectively. Although a statistically significant difference, according to itching and sniff test, was observed among the three groups (P < 0.001, P = 0.005), there was no significant difference between TEE and EO (P = 0.06). Conclusions: The current study showed that the herbal preparation could be used as an alternative antifungal agent for vulvovaginal Candidiasis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherIranian Red Crescent Society
dc.relation.ispartofpagefrome74211:1
dc.relation.ispartofpagetoe74211:10
dc.relation.ispartofissue10
dc.relation.ispartofjournalIranian Red Crescent Medical Journal
dc.relation.ispartofvolume20
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsMedicine, General & Internal
dc.subject.keywordsGeneral & Internal Medicine
dc.subject.keywordsAnethum graveolens
dc.titleComparing the Effect of Dill Seed Vaginal Cream, with a Persian Traditional Base, and 1% Clotrimazole Vaginal Cream on Vulvovaginal Candidiasis: A Double-Blind, Randomized Clinical Trial
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSarhadinejad, Z; Tajadini, H; Tansaz, M; Bahrampour, A; Sarhadynejad, Z; Ansari, M; Sharififar, F; Iranpour, M; Salari, Z, Comparing the Effect of Dill Seed Vaginal Cream, with a Persian Traditional Base, and 1% Clotrimazole Vaginal Cream on Vulvovaginal Candidiasis: A Double-Blind, Randomized Clinical Trial, Iranian Red Crescent Medical Journal, 2018, 20 (10), pp. e74211:1-e74211:10
dcterms.licensehttps://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated2019-10-21T03:42:35Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorBahrampour, Abbas


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