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dc.contributor.authorPetrushnko, W
dc.contributor.authorGundara, JS
dc.contributor.authorDe Reuver, PR
dc.contributor.authorO'Grady, G
dc.contributor.authorSamra, JS
dc.contributor.authorMittal, A
dc.date.accessioned2019-10-21T04:39:57Z
dc.date.available2019-10-21T04:39:57Z
dc.date.issued2016
dc.identifier.issn1365-182X
dc.identifier.doi10.1016/j.hpb.2016.05.004
dc.identifier.urihttp://hdl.handle.net/10072/388574
dc.description.abstractBackground: Pancreatic ductal adenocarcinoma (PDAC) continues to be associated with a poor prognosis. This systematic review aimed to summarize the literature regarding potential prognostic biomarkers to facilitate validation studies and clinical application. Methods: A systematic review was performed (2004–2014) according to PRISMA guidelines. Studies were ranked using REMARK criteria and the following outcomes were examined: overall/disease free survival, nodal involvement, tumour characteristics, metastasis, recurrence and resectability. Results: 256 biomarkers were identified in 158 studies. 171 biomarkers were assessed with respect to overall survival: urokinase-type plasminogen activator receptor, atypical protein kinase C and HSP27 ranked the highest. 33 biomarkers were assessed for disease free survival: CD24 and S100A4 were the highest ranking. 17 biomarkers were identified for lymph node involvement: Smad4/Dpc4 and FOXC1 ranked highest. 13 biomarkers were examined for tumour grade: mesothelin and EGFR were the highest ranking biomarkers. 10 biomarkers were identified for metastasis: p16 and sCD40L were the highest ranking. 4 biomarkers were assessed resectability: sCD40L, s100a2, Ca 19-9, CEA. Conclusion: This review has identified and ranked specific biomarkers that should be a primary focus of ongoing validation and clinical translational work in PDAC.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom652
dc.relation.ispartofpageto663
dc.relation.ispartofissue8
dc.relation.ispartofjournalHPB
dc.relation.ispartofvolume18
dc.subject.fieldofresearchEndocrinology
dc.subject.fieldofresearchGastroenterology and Hepatology
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110306
dc.subject.fieldofresearchcode110307
dc.subject.fieldofresearchcode1103
dc.titleSystematic review of peri-operative prognostic biomarkers in pancreatic ductal adenocarcinoma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPetrushnko, W; Gundara, JS; De Reuver, PR; O'Grady, G; Samra, JS; Mittal, A, Systematic review of peri-operative prognostic biomarkers in pancreatic ductal adenocarcinoma, HPB, 2016, 18 (8), pp. 652-663
dcterms.dateAccepted2016-05-09
dc.date.updated2019-10-21T04:14:01Z
gro.hasfulltextNo Full Text
gro.griffith.authorGundara, Justin


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