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dc.contributor.authorQian, B
dc.contributor.authorVáradi, L
dc.contributor.authorTrinchi, A
dc.contributor.authorReichman, SM
dc.contributor.authorBao, L
dc.contributor.authorLan, M
dc.contributor.authorWei, G
dc.contributor.authorCole, IS
dc.date.accessioned2019-10-23T01:02:41Z
dc.date.available2019-10-23T01:02:41Z
dc.date.issued2019
dc.identifier.issn1420-3049
dc.identifier.doi10.3390/molecules24193569
dc.identifier.urihttp://hdl.handle.net/10072/388626
dc.description.abstractA series of fluorescent coumarin derivatives 2a-e were systematically designed, synthesized and studied for their Cu2+ sensing performance in aqueous media. The sensitivities and selectivities of the on-to-off fluorescent Cu2+ sensing signal were in direct correlation with the relative arrangements of the heteroatoms within the coordinating moieties of these coumarins. Probes 2b and 2d exhibited Cu2+ concentration dependent and selective fluorescence quenching, with linear ranges of 0-80 μM and 0-10 μM, and limits of detection of 0.14 μM and 0.38 μM, respectively. Structural changes of 2b upon Cu2+ coordination were followed by fluorescence titration, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), mass spectrometry, and single crystal X-ray diffraction on the isolated Cu2+-coumarin complex. The results revealed a 1:1 stoichiometry between 2b and Cu2+, and that the essential structural features for Cu2+-selective coordination are the coumarin C=O and a three-bond distance between the amide NH and heterocyclic N. Probe 2b was also used to determine copper (II) levels in aqueous soil extracts, with recovery rates over 80% when compared to the standard soil analysis method: inductively coupled plasma-mass spectrometry (ICP-MS).
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMDPI
dc.publisher.placeSwitzerland
dc.relation.ispartofpagefrom3569:1
dc.relation.ispartofpageto3569:17
dc.relation.ispartofissue19
dc.relation.ispartofjournalMolecules
dc.relation.ispartofvolume24
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchTheoretical and Computational Chemistry
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0307
dc.subject.keywordsCu2+ sensing
dc.subject.keywordscoumarin
dc.subject.keywordsfluorescent quenching
dc.subject.keywordssoil sensing
dc.titleThe Design and Synthesis of Fluorescent Coumarin Derivatives and Their Study for Cu2+ Sensing with an Application for Aqueous Soil Extracts
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationQian, B; Váradi, L; Trinchi, A; Reichman, SM; Bao, L; Lan, M; Wei, G; Cole, IS, The Design and Synthesis of Fluorescent Coumarin Derivatives and Their Study for Cu2+ Sensing with an Application for Aqueous Soil Extracts, Molecules, 2019, 24 (19), pp. 3569: 1-3569: 17
dcterms.dateAccepted2019-10-01
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-10-23T00:27:11Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorCole, Ivan


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