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dc.contributor.authorAnjum, Adiba
dc.contributor.authorBiswas, Sheta
dc.contributor.authorRahman, Mizanur
dc.contributor.authorRahman, Atiqur
dc.contributor.authorSiddique, Abu Eabrahim
dc.contributor.authorKarim, Yeasir
dc.contributor.authorAktar, Sharmin
dc.contributor.authorNikkon, Farjana
dc.contributor.authorHaque, Azizul
dc.contributor.authorHimeno, Seiichiro
dc.contributor.authorHossain, Khaled
dc.contributor.authorSaud, Zahangir Alam
dc.date.accessioned2019-10-25T04:58:19Z
dc.date.available2019-10-25T04:58:19Z
dc.date.issued2019
dc.identifier.issn0944-1344
dc.identifier.doi10.1007/s11356-018-04066-1
dc.identifier.urihttp://hdl.handle.net/10072/388699
dc.description.abstractGroundwater particularly drinking water contamination with metals has created an environmental disaster in Bangladesh. Manganese (Mn), an essential trace element, plays a key role in the development and function of the brain. Excess Mn exposure is reported to be associated with complex neurological disorders. Here, we have found a notably large extent of Mn above the permissive limit in the tube-well water of Rajshahi and Naogaon districts in Bangladesh. Higher levels of Mn in hair and nail samples, and a decreasing level of butyrylcholinesterase (BChE) activity were detected in plasma samples of the human subjects recruited from Naogaon district. Mn concentrations in water, hair, and nails were negatively correlated with the plasma BChE levels in Mn-exposed populations. To compare and validate these human studies, an animal model was used to determine the in vivo effects of Mn on neurobehavioral changes and blood BChE levels. In elevated plus maze, the time spent was significantly reduced in open arms and increased in closed arms of Mn-exposed mice compared to control group. The mean latency time to find the platform was declined significantly in control mice compared to Mn-treated group during 7 days in Morris water maze test, and Mn-exposed group also spent significantly less time in the desired quadrant as compared to the control group in probe trial. BChE activity was significantly reduced in Mn-exposed mice compared to control mice. Taken together, these results suggest that plasma BChE levels may serve as reliable biomarker of Mn-induced neurotoxicity related to behavioral changes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofpagefrom6378
dc.relation.ispartofpageto6387
dc.relation.ispartofissue7
dc.relation.ispartofjournalEnvironmental Science and Pollution Research
dc.relation.ispartofvolume26
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchEnvironmental sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode41
dc.subject.fieldofresearchcode31
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsEnvironmental Sciences & Ecology
dc.subject.keywordsGroundwater
dc.titleButyrylcholinesterasea potential plasma biomarker in manganese-induced neurobehavioral changes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationAnjum, A; Biswas, S; Rahman, M; Rahman, A; Siddique, AE; Karim, Y; Aktar, S; Nikkon, F; Haque, A; Himeno, S; Hossain, K; Saud, ZA, Butyrylcholinesterasea potential plasma biomarker in manganese-induced neurobehavioral changes, Environmental Science and Pollution Research, 2019, 26 (7), pp. 6378-6387
dcterms.dateAccepted2018-12-20
dc.date.updated2019-10-25T01:13:02Z
gro.hasfulltextNo Full Text
gro.griffith.authorAktar, Sharmin


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