Show simple item record

dc.contributor.authorChacko, Anu
dc.contributor.authorBeagley, Kenneth W
dc.contributor.authorTimms, Peter
dc.contributor.authorHuston, Wilhelmina M
dc.date.accessioned2019-10-30T06:48:12Z
dc.date.available2019-10-30T06:48:12Z
dc.date.issued2015
dc.identifier.issn1574-6968en_US
dc.identifier.doi10.1093/femsle/fnv015en_US
dc.identifier.urihttp://hdl.handle.net/10072/388788
dc.description.abstractChlamydia pneumoniae strains have recently been demonstrated to have substantially different capacities to enter and recover from IFN-γ-induced persistence, depending on whether they are from human or animal host sources. Here, we examined the ability of two human and two animal strains to enter and be rescued from penicillin-induced persistence. The ability to form inclusions after the addition of penicillin was much reduced in the two animal isolates (koala LPCoLN, bandicoot B21) compared to the two human isolates (respiratory AR39 and heart A03). The penicillin treatment resulted in a dose-dependent loss of infectious progeny for all isolates, with the human strains failing to produce infectious progeny at lower doses of penicillin than the animal strains. The most remarkable finding however was the contrasting ability of the isolates to recover infectious progeny production after rescue by removal of the penicillin (at 72 h) and continued culture. The animal isolates both showed virtually no recovery from the penicillin treatment conditions. In contrast, the human isolates showed a significant ability to recovery infectivity, with the heart isolate (A03) showing the most marked recovery. Combined, these data further support the hypothesis that the ability to establish and recover from persistence appears to be enhanced in human C. pneumoniae strains compared to animal strains.en_US
dc.languageenen_US
dc.publisherOxford University Press (OUP)en_US
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto7en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalFEMS Microbiology Lettersen_US
dc.relation.ispartofvolume362en_US
dc.subject.fieldofresearchBiological Sciencesen_US
dc.subject.fieldofresearchMedical and Health Sciencesen_US
dc.subject.fieldofresearchAgricultural and Veterinary Sciencesen_US
dc.subject.fieldofresearchcode06en_US
dc.subject.fieldofresearchcode11en_US
dc.subject.fieldofresearchcode07en_US
dc.titleHuman Chlamydia pneumoniae isolates demonstrate ability to recover infectivity following penicillin treatment whereas animal isolates do noten_US
dc.typeJournal articleen_US
dcterms.bibliographicCitationChacko, A; Beagley, KW; Timms, P; Huston, WM, Human Chlamydia pneumoniae isolates demonstrate ability to recover infectivity following penicillin treatment whereas animal isolates do not, FEMS Microbiology Letters, 2015, 362 (6)en_US
dc.date.updated2019-10-29T02:06:21Z
dc.description.versionPost-printen_US
gro.rights.copyright© 2015 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in FEMS Microbiology Letters following peer review. The definitive publisher-authenticated version Human Chlamydia pneumoniae isolates demonstrate ability to recover infectivity following penicillin treatment whereas animal isolates do not, FEMS Microbiology Letters, Volume 362, Issue 6, 2015 is available online at: https://doi.org/10.1093/femsle/fnv015.en_US
gro.hasfulltextFull Text
gro.griffith.authorChacko, Anu


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record