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dc.contributor.authorChacko, Anu
dc.contributor.authorBeagley, Kenneth W
dc.contributor.authorTimms, Peter
dc.contributor.authorHuston, Wilhelmina M
dc.date.accessioned2019-10-30T06:48:12Z
dc.date.available2019-10-30T06:48:12Z
dc.date.issued2015
dc.identifier.issn0378-1097
dc.identifier.doi10.1093/femsle/fnv015
dc.identifier.urihttp://hdl.handle.net/10072/388788
dc.description.abstractChlamydia pneumoniae strains have recently been demonstrated to have substantially different capacities to enter and recover from IFN-γ-induced persistence, depending on whether they are from human or animal host sources. Here, we examined the ability of two human and two animal strains to enter and be rescued from penicillin-induced persistence. The ability to form inclusions after the addition of penicillin was much reduced in the two animal isolates (koala LPCoLN, bandicoot B21) compared to the two human isolates (respiratory AR39 and heart A03). The penicillin treatment resulted in a dose-dependent loss of infectious progeny for all isolates, with the human strains failing to produce infectious progeny at lower doses of penicillin than the animal strains. The most remarkable finding however was the contrasting ability of the isolates to recover infectious progeny production after rescue by removal of the penicillin (at 72 h) and continued culture. The animal isolates both showed virtually no recovery from the penicillin treatment conditions. In contrast, the human isolates showed a significant ability to recovery infectivity, with the heart isolate (A03) showing the most marked recovery. Combined, these data further support the hypothesis that the ability to establish and recover from persistence appears to be enhanced in human C. pneumoniae strains compared to animal strains.
dc.languageEnglish
dc.publisherOxford University Press (OUP)
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto7
dc.relation.ispartofissue6
dc.relation.ispartofjournalFEMS Microbiology Letters
dc.relation.ispartofvolume362
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleHuman Chlamydia pneumoniae isolates demonstrate ability to recover infectivity following penicillin treatment whereas animal isolates do not
dc.typeJournal article
dcterms.bibliographicCitationChacko, A; Beagley, KW; Timms, P; Huston, WM, Human Chlamydia pneumoniae isolates demonstrate ability to recover infectivity following penicillin treatment whereas animal isolates do not, FEMS Microbiology Letters, 2015, 362 (6)
dc.date.updated2019-10-29T02:06:21Z
dc.description.versionPost-print
gro.rights.copyright© 2015 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in FEMS Microbiology Letters following peer review. The definitive publisher-authenticated version Human Chlamydia pneumoniae isolates demonstrate ability to recover infectivity following penicillin treatment whereas animal isolates do not, FEMS Microbiology Letters, Volume 362, Issue 6, 2015 is available online at: https://doi.org/10.1093/femsle/fnv015.
gro.hasfulltextFull Text
gro.griffith.authorChacko, Anu


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