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dc.contributor.authorCampling, J
dc.contributor.authorJones, D
dc.contributor.authorChalmers, JD
dc.contributor.authorJiang, Q
dc.contributor.authorVyse, A
dc.contributor.authorMadhava, H
dc.contributor.authorEllsbury, G
dc.contributor.authorSlack, M
dc.date.accessioned2019-11-04T03:33:56Z
dc.date.available2019-11-04T03:33:56Z
dc.date.issued2019
dc.identifier.issn2200-6133en_US
dc.identifier.doi10.1186/s41479-019-0063-zen_US
dc.identifier.urihttp://hdl.handle.net/10072/388876
dc.description.abstractBackground: UK specific data on the risk of developing hospitalised CAP for patients with underlying comorbidities is lacking. This study compared the likelihood of hospitalised all-cause community acquired pneumonia (CAP) in patients with certain high-risk comorbidities and a comparator group with no known risk factors for pneumococcal disease. Methods: This retrospective cohort study interrogated data in the Hospital Episodes Statistics (HES) dataset between financial years 2012/13 and 2016/17. In total 3,078,623 patients in England (aged ≥18 years) were linked to their hospitalisation records. This included 2,950,910 individuals with defined risk groups and a comparator group of 127,713 people who had undergone tooth extraction with none of the risk group diagnoses. Risk groups studied were chronic respiratory disease (CRD), chronic heart disease (CHD), chronic liver disease (CLD), chronic kidney disease (CKD), diabetes (DM) and post bone marrow transplant (BMT). The patients were tracked forward from year 0 (2012/13) to Year 3 (2016/17) and all diagnoses of hospitalised CAP were recorded. A Logistic regression model compared odds of developing hospitalised CAP for patients in risk groups compared to healthy controls. The model was simultaneously adjusted for age, sex, strategic heath authority (SHA), index of multiple deprivation (IMD), ethnicity, and comorbidity. To account for differing comorbidity profiles between populations the Charlson Comorbidity Index (CCI) was applied. The model estimated odds ratios (OR) with 95% confidence intervals of developing hospitalised CAP for each specified clinical risk group. Results: Patients within all the risk groups studied were more likely to develop hospitalised CAP than patients in the comparator group. The odds ratios varied between underlying conditions ranging from 1.18 (95% CI 1.13, 1.23) for those with DM to 5.48 (95% CI 5.28, 5.70) for those with CRD. Conclusions: Individuals with any of 6 pre-defined underlying comorbidities are at significantly increased risk of developing hospitalised CAP compared to those with no underlying comorbid condition. Since the likelihood varies by risk group it should be possible to target patients with each of these underlying comorbidities with the most appropriate preventative measures, including immunisations.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherBioMed Centralen_US
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom4: 1en_US
dc.relation.ispartofpageto4: 8en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalPneumonia (Nathan)en_US
dc.relation.ispartofvolume11en_US
dc.subject.fieldofresearchClinical Sciencesen_US
dc.subject.fieldofresearchOther Medical and Health Sciencesen_US
dc.subject.fieldofresearchcode1103en_US
dc.subject.fieldofresearchcode1199en_US
dc.subject.keywordsBig dataen_US
dc.subject.keywordsHospital episodes statistics (HES) databaseen_US
dc.subject.keywordsHospitalised community acquired pneumonia (CAP)en_US
dc.subject.keywordsLinkageen_US
dc.subject.keywordsPneumococcusen_US
dc.titleThe impact of certain underlying comorbidities on the risk of developing hospitalised pneumonia in England.en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationCampling, J; Jones, D; Chalmers, JD; Jiang, Q; Vyse, A; Madhava, H; Ellsbury, G; Slack, M, The impact of certain underlying comorbidities on the risk of developing hospitalised pneumonia in England., Pneumonia (Nathan), 2019, 11 (1), pp. 4: 1-4: 8en_US
dcterms.dateAccepted2019-09-12
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2019-11-03T23:36:15Z
dc.description.versionPublisheden_US
gro.rights.copyright© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
gro.hasfulltextFull Text
gro.griffith.authorSlack, Mary P.


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