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dc.contributor.authorYelland, Michael
dc.contributor.authorRabago, David
dc.contributor.authorRyan, Michael
dc.contributor.authorNg, Shu-Kay
dc.contributor.authorVithanachchi, Dinusha
dc.contributor.authorManickaraj, Nagarajan
dc.contributor.authorBisset, Leanne
dc.date.accessioned2019-11-08T05:55:52Z
dc.date.available2019-11-08T05:55:52Z
dc.date.issued2019
dc.identifier.issn1471-2474
dc.identifier.doi10.1186/s12891-019-2905-5
dc.identifier.urihttp://hdl.handle.net/10072/389007
dc.description.abstractBACKGROUND: Lateral epicondylalgia (tennis elbow) is a common, debilitating and often treatment-resistant condition. Two treatments thought to address the pathology of lateral epicondylalgia are hypertonic glucose plus lignocaine injections (prolotherapy) and a physiotherapist guided manual therapy/exercise program (physiotherapy). This trial aimed to compare the short- and long-term clinical effectiveness, cost effectiveness, and safety of prolotherapy used singly and in combination with physiotherapy. METHODS: Using a single-blinded randomised clinical trial design, 120 participants with lateral epicondylalgia of at least 6 weeks' duration were randomly assigned to prolotherapy (4 sessions, monthly intervals), physiotherapy (weekly for 4 sessions) or combined (prolotherapy+physiotherapy). The Patient-Rated Tennis Elbow Evaluation (PRTEE) and participant global impression of change scores were assessed by blinded evaluators at baseline, 6, 12, 26 and 52 weeks. Success rate was defined as the percentage of participants indicating elbow condition was either 'much improved' or 'completely recovered.' Analysis was by intention-to-treat. RESULTS: Eighty-eight percent completed the 12-month assessment. At 52 weeks, there were substantial, significant improvements compared with baseline status for all outcomes and groups, but no significant differences between groups. The physiotherapy group exhibited greater reductions in PRTEE at 12 weeks than the prolotherapy group (p = 0.014). CONCLUSION: There were no significant differences amongst the Physiotherapy, Prolotherapy and Combined groups in PRTEE and global impression of change measures over the course of the 12-month trial. TRIAL REGISTRATION: ACTRN12612000993897 .
dc.description.peerreviewedYes
dc.languageeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom509: 1
dc.relation.ispartofpageto509: 10
dc.relation.ispartofissue1
dc.relation.ispartofjournalBMC Musculoskeletal Disorders
dc.relation.ispartofvolume20
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.subject.keywordsElbow
dc.subject.keywordsInjection
dc.subject.keywordsLateral epicondylalgia
dc.subject.keywordsPhysiotherapy
dc.subject.keywordsProlotherapy
dc.titleProlotherapy injections and physiotherapy used singly and in combination for lateral epicondylalgia: a single-blinded randomised clinical trial.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYelland, M; Rabago, D; Ryan, M; Ng, S-K; Vithanachchi, D; Manickaraj, N; Bisset, L, Prolotherapy injections and physiotherapy used singly and in combination for lateral epicondylalgia: a single-blinded randomised clinical trial., BMC Musculoskeletal Disorders, 2019, 20 (1), pp. 509: 1-509: 10
dcterms.dateAccepted2019-10-22
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-11-08T01:07:58Z
dc.description.versionPublished
gro.rights.copyright© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorBisset, Leanne M.


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