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dc.contributor.authorCoombes, BK
dc.contributor.authorTucker, K
dc.contributor.authorHug, F
dc.contributor.authorScott, A
dc.contributor.authorGeytenbeek, M
dc.contributor.authorCox, ER
dc.contributor.authorGajanand, T
dc.contributor.authorCoombes, JS
dc.date.accessioned2019-11-11T04:38:47Z
dc.date.available2019-11-11T04:38:47Z
dc.date.issued2019
dc.identifier.issn2240-4554
dc.identifier.doi10.32098/mltj.03.2019.14
dc.identifier.urihttp://hdl.handle.net/10072/389036
dc.description.abstractBackground. Patients with diabetes have 44% greater risk of tendon rupture requiring hospitalisation. Despite this, in vivo research of the associations of diabetes and other cardiovascular disease risk factors on structural and mechanical properties of the Achilles tendon are sparsely studied. Methods. Inactive individuals with type 2 diabetes (n=33) underwent ultrasound and shear wave elastography imaging of their Achilles tendons bilaterally to measure thickness and shear wave velocity (SWV), an index of tendon elastic modulus. In a separate session, participants underwent assessment of body composition, cardiorespiratory fitness and blood biomarkers. Seven inactive individuals without type 2 diabetes were recruited for comparison of tendon structural and mechanical properties. Results. In participants with diabetes, free tendon SWV displayed large negative correlations with hip circumference (r=-0.67, P <0.001), waist circumference (r=-0.59, P <0.001) and body mass index (r=-0.52, P <0001), and a moderate positive correlation with VO2 peak (r=0.34, P =0.006). SWV was lower in participants with diabetes taking statins compared to not taking statins (Free tendon: median difference 8%, P=0.004); insertion: 11%, P =0.001). Compared to the control group, the diabetes group had thicker Achilles free tendon (median difference 15%, P<0.001) and Achilles insertion (17%, P=0.006), but no differences in SWV (P=0.490 or 0.577 respectively). Conclusions. Achilles tendons from individuals with type 2 diabetes were thicker compared to inactive individuals without diabetes. Adiposity, statin use and low cardiorespiratory fitness were associated with inferior Achilles tendon mechanical properties in people with diabetes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherEdra SpA
dc.relation.ispartofpagefrom395
dc.relation.ispartofpageto404
dc.relation.ispartofissue3
dc.relation.ispartofjournalMuscles, Ligaments and Tendons Journal
dc.relation.ispartofvolume9
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPhysiology
dc.subject.fieldofresearchHuman Movement and Sports Sciences
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode0606
dc.subject.fieldofresearchcode1106
dc.subject.fieldofresearchcode1116
dc.titleRelationships between cardiovascular disease risk factors and achilles tendon structural and mechanical properties in people with type 2 diabetes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCoombes, BK; Tucker, K; Hug, F; Scott, A; Geytenbeek, M; Cox, ER; Gajanand, T; Coombes, JS, Relationships between cardiovascular disease risk factors and achilles tendon structural and mechanical properties in people with type 2 diabetes, Muscles, Ligaments and Tendons Journal, 2019, 9 (3), pp. 395-404
dc.date.updated2019-11-07T13:37:27Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 Italian Society of Muscles, Ligaments and Tendons– I.S.Mu.L.T. Published by Edra SpA. All Rights reserved.The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorCoombes, Brooke K.


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