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  • Investigation of Sustained BMP Delivery in the Prevention of Medication-Related Osteonecrosis of the Jaw (MRONJ) in a Rat Model

    Author(s)
    Brierly, Gary I
    Ren, Jiongyu
    Baldwin, Jeremy
    Saifzadeh, Siamak
    Theodoropoulos, Christina
    Tsurkan, Mikhail V
    Lynham, Anthony
    Hsu, Edward
    Nikolarakos, Dimitrios
    Werner, Carsten
    Woodruff, Maria A
    Hutmacher, Dietmar W
    Bray, Laura J
    Griffith University Author(s)
    Hutmacher, Dietmar W.
    Year published
    2019
    Metadata
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    Abstract
    Medication-related osteonecrosis of the jaw (MRONJ) poses an ongoing challenge for clinicians and researchers. Currently, there is a lack of preventative measures available for at-risk patients undergoing tooth extractions, especially those with prior bisphosphonate treatment due to osteoporosis or bone metastasis diagnoses. Here, these issues are addressed using a preventative tissue engineering strategy against MRONJ development. This study evaluates the efficacy of a poly(ethylene glycol)-heparin hydrogel as a tool for the delivery of arginylglycylaspartic acid (RGD) and recombinant human bone morphogenic protein-2 ...
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    Medication-related osteonecrosis of the jaw (MRONJ) poses an ongoing challenge for clinicians and researchers. Currently, there is a lack of preventative measures available for at-risk patients undergoing tooth extractions, especially those with prior bisphosphonate treatment due to osteoporosis or bone metastasis diagnoses. Here, these issues are addressed using a preventative tissue engineering strategy against MRONJ development. This study evaluates the efficacy of a poly(ethylene glycol)-heparin hydrogel as a tool for the delivery of arginylglycylaspartic acid (RGD) and recombinant human bone morphogenic protein-2 (rhBMP-2). Three groups of skeletally mature rats each receive two doses of intravenous zoledronic acid prior to surgery and undergo extraction of the right first mandibular molar with gingival closure. Experimental groups either have the sockets left empty, filled with hydrogel minus rhBMP-2, or filled with hydrogel plus rhBMP-2. Eight weeks postoperatively specimens are analyzed using radiological, histological, and scanning electron microscopy (SEM) techniques. µCT analysis shows increased bone formation with hydrogel/rhBMP-2 delivery compared to the empty socket. Hydrogel-treated groups display increased presence of osteocytes and increased osteoclastic action compared to the empty sockets. These results represent the first step toward improved delivery of rhBMP-2 and a potential MRONJ preventative for patients undergoing bisphosphonate treatment.
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    Journal Title
    Macromolecular Bioscience
    Volume
    19
    Issue
    11
    DOI
    https://doi.org/10.1002/mabi.201900226
    Subject
    Macromolecular and materials chemistry
    Biomedical engineering
    Chemical engineering
    Science & Technology
    Life Sciences & Biomedicine
    Technology
    Physical Sciences
    Biochemistry & Molecular Biology
    Publication URI
    http://hdl.handle.net/10072/389043
    Collection
    • Journal articles

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