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dc.contributor.authorBrierly, Gary I
dc.contributor.authorRen, Jiongyu
dc.contributor.authorBaldwin, Jeremy
dc.contributor.authorSaifzadeh, Siamak
dc.contributor.authorTheodoropoulos, Christina
dc.contributor.authorTsurkan, Mikhail V
dc.contributor.authorLynham, Anthony
dc.contributor.authorHsu, Edward
dc.contributor.authorNikolarakos, Dimitrios
dc.contributor.authorWerner, Carsten
dc.contributor.authorWoodruff, Maria A
dc.contributor.authorHutmacher, Dietmar W
dc.contributor.authorBray, Laura J
dc.date.accessioned2019-11-11T06:20:40Z
dc.date.available2019-11-11T06:20:40Z
dc.date.issued2019
dc.identifier.issn1616-5187
dc.identifier.doi10.1002/mabi.201900226
dc.identifier.urihttp://hdl.handle.net/10072/389043
dc.description.abstractMedication-related osteonecrosis of the jaw (MRONJ) poses an ongoing challenge for clinicians and researchers. Currently, there is a lack of preventative measures available for at-risk patients undergoing tooth extractions, especially those with prior bisphosphonate treatment due to osteoporosis or bone metastasis diagnoses. Here, these issues are addressed using a preventative tissue engineering strategy against MRONJ development. This study evaluates the efficacy of a poly(ethylene glycol)-heparin hydrogel as a tool for the delivery of arginylglycylaspartic acid (RGD) and recombinant human bone morphogenic protein-2 (rhBMP-2). Three groups of skeletally mature rats each receive two doses of intravenous zoledronic acid prior to surgery and undergo extraction of the right first mandibular molar with gingival closure. Experimental groups either have the sockets left empty, filled with hydrogel minus rhBMP-2, or filled with hydrogel plus rhBMP-2. Eight weeks postoperatively specimens are analyzed using radiological, histological, and scanning electron microscopy (SEM) techniques. µCT analysis shows increased bone formation with hydrogel/rhBMP-2 delivery compared to the empty socket. Hydrogel-treated groups display increased presence of osteocytes and increased osteoclastic action compared to the empty sockets. These results represent the first step toward improved delivery of rhBMP-2 and a potential MRONJ preventative for patients undergoing bisphosphonate treatment.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.publisher.placeGermany
dc.relation.ispartofpagefrom1900226:1
dc.relation.ispartofpageto1900226:10
dc.relation.ispartofissue11
dc.relation.ispartofjournalMacromolecular Bioscience
dc.relation.ispartofvolume19
dc.subject.fieldofresearchMacromolecular and Materials Chemistry
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchChemical Engineering
dc.subject.fieldofresearchcode0303
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode0904
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsTechnology
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsBiochemistry & Molecular Biology
dc.titleInvestigation of Sustained BMP Delivery in the Prevention of Medication-Related Osteonecrosis of the Jaw (MRONJ) in a Rat Model
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBrierly, GI; Ren, J; Baldwin, J; Saifzadeh, S; Theodoropoulos, C; Tsurkan, MV; Lynham, A; Hsu, E; Nikolarakos, D; Werner, C; Woodruff, MA; Hutmacher, DW; Bray, LJ, Investigation of Sustained BMP Delivery in the Prevention of Medication-Related Osteonecrosis of the Jaw (MRONJ) in a Rat Model, Macromolecular Bioscience, 2019 19 (11), pp. 1900226:1-1900226:10
dc.date.updated2019-11-11T01:25:28Z
gro.hasfulltextNo Full Text
gro.griffith.authorHutmacher, Dietmar W.


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