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dc.contributor.authorLutke Schipholt, IJ
dc.contributor.authorScholten-Peeters, GGM
dc.contributor.authorBontkes, HJ
dc.contributor.authorCoppieters, MW
dc.date.accessioned2019-11-12T01:35:00Z
dc.date.available2019-11-12T01:35:00Z
dc.date.issued2019
dc.identifier.issn1529-9430
dc.identifier.doi10.1016/j.spinee.2019.06.013
dc.identifier.urihttp://hdl.handle.net/10072/389060
dc.description.abstractWe wholeheartedly agree with Klyne and Hodges [1] who emphasized in response to our Perspective [2] that the association between systemic inflammation and musculoskeletal pain is complex. In our Perspective, we called for a prudent interpretation of the literature because multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A recent systematic review reiterated our viewpoint (“The potential role of confounding factors on the association between (pro)inflammatory biomarkers and nonspecific low back pain needs to be better controlled for and/or evaluated in future research”) [3]. Furthermore, we proposed to create a core set of potentially important confounders to assist researchers with their selection of factors. This was also echoed by the authors of another recent systematic review who “did not find relevant information in the literature to decide a-priori which confounders would be the most relevant in this field” [4]. Although we focussed on confounders in our Perspective, Klyne and Hodges [1] appropriately expanded on the topic and highlighted the distinction between confounders and mediators in their Letter-to-the-Editor.
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofpagefrom1901
dc.relation.ispartofpageto1901
dc.relation.ispartofissue11
dc.relation.ispartofjournalSpine Journal
dc.relation.ispartofvolume19
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1103
dc.titleAuthors' Reply: Confounding and mediation to reveal the true association between systemic inflammation and musculoskeletal pain
dc.typeJournal article
dc.type.descriptionC2 - Articles (Other)
dcterms.bibliographicCitationLutke Schipholt, IJ; Scholten-Peeters, GGM; Bontkes, HJ; Coppieters, MW, Authors' Reply: Confounding and mediation to reveal the true association between systemic inflammation and musculoskeletal pain, Spine Journal, 2019, 19 (11), pp. 1901-1901
dc.date.updated2019-11-08T03:39:53Z
gro.hasfulltextNo Full Text
gro.griffith.authorCoppieters, Michel


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