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dc.contributor.authorYang, ZY
dc.contributor.authorWang, SK
dc.contributor.authorLi, Y
dc.contributor.authorWang, Y
dc.contributor.authorWang, YM
dc.contributor.authorZhou, HY
dc.contributor.authorCai, XL
dc.contributor.authorCheung, EFC
dc.contributor.authorShum, DHK
dc.contributor.authorÖngür, D
dc.contributor.authorChan, RCK
dc.date.accessioned2019-11-12T03:56:49Z
dc.date.available2019-11-12T03:56:49Z
dc.date.issued2019
dc.identifier.issn0925-4927
dc.identifier.doi10.1016/j.pscychresns.2019.110987
dc.identifier.urihttp://hdl.handle.net/10072/389074
dc.description.abstractProspection, which has a close relationship with motivation and goal-directed behavior, could be a potential target for alleviating negative symptoms. The present study aimed to examine the structural neural correlates of prospection impairments and the involvement of working memory in prospection in schizophrenia patients. Thirty-seven patients with schizophrenia and 28 healthy controls were recruited and all of them completed a prospection task. Working memory was assessed with the Letter Number Span test. In addition, all participants underwent a structural MRI scan. Voxel-based morphometry (VBM) analysis was used to measure grey matter (GM) volume. We found that in schizophrenia patients, GM loss in the right lateral prefrontal cortex (PFC) and the right ventral medial PFC was correlated with decreased internal details in the prospection task. Moreover, GM volume of the right lateral PFC was found to mediate the relationship between working memory and internal details in these patients. In conclusion, GM loss in the PFC is associated with prospection impairments in schizophrenia patients. Working memory deficits may partially account for prospection impairments in schizophrenia patients.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofpagefrom110987:1
dc.relation.ispartofpageto110987:6
dc.relation.ispartofjournalPsychiatry Research - Neuroimaging
dc.relation.ispartofvolume293
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5204
dc.titleNeural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationYang, ZY; Wang, SK; Li, Y; Wang, Y; Wang, YM; Zhou, HY; Cai, XL; Cheung, EFC; Shum, DHK; Öngür, D; Chan, RCK, Neural correlates of prospection impairments in schizophrenia: Evidence from voxel-based morphometry analysis, Psychiatry Research - Neuroimaging, 2019, 293, pp. 110987:1-110987:6
dc.date.updated2019-10-31T05:45:23Z
gro.hasfulltextNo Full Text
gro.griffith.authorShum, David
gro.griffith.authorChan, Raymond


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