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dc.contributor.authorBarnden, LR
dc.contributor.authorShan, ZY
dc.contributor.authorStaines, DR
dc.contributor.authorMarshall-Gradisnik, S
dc.contributor.authorFinegan, K
dc.contributor.authorIreland, T
dc.contributor.authorBhuta, S
dc.date.accessioned2019-11-13T01:33:40Z
dc.date.available2019-11-13T01:33:40Z
dc.date.issued2019
dc.identifier.issn2213-1582
dc.identifier.doi10.1016/j.nicl.2019.102045
dc.identifier.urihttp://hdl.handle.net/10072/389111
dc.description.abstractIn myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), abnormal MRI correlations with symptom severity and autonomic measures have suggested impaired nerve signal conduction within the brainstem. Here we analyse fMRI correlations to directly test connectivity within and from the brainstem. Resting and task functional MRI (fMRI) were acquired for 45 ME/CFS (Fukuda criteria) and 27 healthy controls (HC). We selected limited brainstem reticular activation system (RAS) regions-of-interest (ROIs) based on previous structural MRI findings in a different ME/CFS cohort (bilateral rostral medulla and midbrain cuneiform nucleus), the dorsal Raphe nucleus, and two subcortical ROIs (hippocampus subiculum and thalamus intralaminar nucleus) reported to have rich brainstem connections. When HC and ME/CFS were analysed separately, significant correlations were detected for both groups during both rest and task, with stronger correlations during task than rest. In ME/CFS, connections were absent between medulla and midbrain nuclei, although hippocampal connections with these nuclei were enhanced. When corresponding correlations from HC and ME/CFS were compared, ME/CFS connectivity deficits were detected within the brainstem between the medulla and cuneiform nucleus and between the brainstem and hippocampus and intralaminar thalamus, but only during task. In CFS/ME, weaker connectivity between some RAS nuclei was associated with increased symptom severity. RAS neuron oscillatory signals facilitate coherence in thalamo-cortical oscillations. Brainstem RAS connectivity deficits can explain autonomic changes and diminish cortical oscillatory coherence which can impair attention, memory, cognitive function, sleep quality and muscle tone, all symptoms of ME/CFS.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier BV
dc.publisher.placeNetherlands
dc.relation.ispartofpagefrom102045: 1
dc.relation.ispartofpageto102045: 7
dc.relation.ispartofjournalNeuroImage: Clinical
dc.relation.ispartofvolume24
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode1109
dc.subject.keywordsBrainstem
dc.subject.keywordsChronic fatigue syndrome
dc.subject.keywordsCoherent
dc.subject.keywordsConnectivity
dc.subject.keywordsCuneiform nucleus
dc.titleIntra brainstem connectivity is impaired in chronic fatigue syndrome
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationBarnden, LR; Shan, ZY; Staines, DR; Marshall-Gradisnik, S; Finegan, K; Ireland, T; Bhuta, S, Intra brainstem connectivity is impaired in chronic fatigue syndrome, NeuroImage: Clinical, 2019, 24, pp. 102045: 1-102045: 7
dcterms.dateAccepted2019-10-17
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2019-11-07T01:31:13Z
dc.description.versionPublished
gro.rights.copyright© 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorBhuta, Sandeep
gro.griffith.authorBarnden, Leighton
gro.griffith.authorStaines, Don R.
gro.griffith.authorMarshall-Gradisnik, Sonya M.
gro.griffith.authorFinegan, Kevin
gro.griffith.authorIreland, Timothy
gro.griffith.authorShan, Zack


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