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dc.contributor.authorRosenfield, David
dc.contributor.authorSmits, Jasper AJ
dc.contributor.authorHofmann, Stefan G
dc.contributor.authorMataix-Cols, David
dc.contributor.authorde la Cruz, Lorena Fernández
dc.contributor.authorAndersson, Erik
dc.contributor.authorRück, Christian
dc.contributor.authorMonzani, Benedetta
dc.contributor.authorPérez-Vigil, Ana
dc.contributor.authorFrumento, Paolo
dc.contributor.authorDavis, Michael
dc.contributor.authorde Kleine, Rianne A
dc.contributor.authorDifede, JoAnn
dc.contributor.authorDunlop, Boadie W
dc.contributor.authorFarrell, Lara J
dc.contributor.authorGeller, Daniel
dc.contributor.authorGerardi, Maryrose
dc.contributor.authorGuastella, Adam J
dc.contributor.authorHendriks, Gert-Jan
dc.contributor.authorKushner, Matt G
dc.contributor.authorLee, Francis S
dc.contributor.authorLenze, Eric J
dc.contributor.authorLevinson, Cheri A
dc.contributor.authorMcConnell, Harry
dc.contributor.authorPlag, Jens
dc.contributor.authorPollack, Mark H
dc.contributor.authorRessler, Kerry J
dc.contributor.authorRodebaugh, Thomas L
dc.contributor.authorRothbaum, Barbara O
dc.contributor.authorStorch, Eric A
dc.contributor.authorStröhle, Andreas
dc.contributor.authorTart, Candyce D
dc.contributor.authorTolin, David F
dc.contributor.authorvan Minnen, Agnes
dc.contributor.authorWaters, Allison M
dc.contributor.authorWeems, Carl F
dc.contributor.authorWilhelm, Sabine
dc.contributor.authorWyka, Katarzyna
dc.contributor.authorAltemus, Margaret
dc.contributor.authorAnderson, Page
dc.contributor.authorCukor, Judith
dc.contributor.authorFinck, Claudia
dc.contributor.authorGeffken, Gary R
dc.contributor.authorGolfels, Fabian
dc.contributor.authorGoodman, Wayne K
dc.contributor.authorGutner, Cassidy A
dc.contributor.authorHeyman, Isobel
dc.contributor.authorJovanovic, Tanja
dc.contributor.authorLewin, Adam B
dc.contributor.authorMcNamara, Joseph P
dc.contributor.authorMurphy, Tanya K
dc.contributor.authorNorrholm, Seth
dc.contributor.authorThuras, Paul
dc.contributor.authorTurner, Cynthia
dc.contributor.authorOtto, Michael W
dc.date.accessioned2019-11-13T04:39:07Z
dc.date.available2019-11-13T04:39:07Z
dc.date.issued2019
dc.identifier.issn0887-6185
dc.identifier.doi10.1016/j.janxdis.2019.102149
dc.identifier.urihttp://hdl.handle.net/10072/389135
dc.description.abstractThe apparent efficacy of d-cycloserine (DCS) for enhancing exposure treatment for anxiety disorders appears to have declined over the past 14 years. We examined whether variations in how DCS has been administered can account for this “declining effect”. We also investigated the association between DCS administration characteristics and treatment outcome to find optimal dosing parameters. We conducted a secondary analysis of individual participant data obtained from 1047 participants in 21 studies testing the efficacy of DCS-augmented exposure treatments. Different outcome measures in different studies were harmonized to a 0-100 scale. Intent-to-treat analyses showed that, in participants randomized to DCS augmentation (n = 523), fewer DCS doses, later timing of DCS dose, and lower baseline severity appear to account for this decline effect. More DCS doses were related to better outcomes, but this advantage leveled-off at nine doses. Administering DCS more than 60 minutes before exposures was also related to better outcomes. These predictors were not significant in the placebo arm (n = 521). Results suggested that optimal DCS administration could increase pre-to-follow-up DCS effect size by 50%. In conclusion, the apparent declining effectiveness of DCS over time may be accounted for by how it has been administered. Optimal DCS administration may substantially improve outcomes.
dc.description.peerreviewedYes
dc.description.sponsorshipAustralian Rotary Health Research Fund
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeElsevier
dc.relation.ispartofpagefrom102149: 1
dc.relation.ispartofpageto102149: 8
dc.relation.ispartofjournalJournal of Anxiety Disorders
dc.relation.ispartofvolume68
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchClinical and health psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5204
dc.subject.fieldofresearchcode5203
dc.titleChanges in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRosenfield, D; Smits, JAJ; Hofmann, SG; Mataix-Cols, D; de la Cruz, LF; Andersson, E; Rück, C; Monzani, B; Pérez-Vigil, A; Frumento, P; Davis, M; de Kleine, RA; Difede, J; Dunlop, BW; Farrell, LJ; Geller, D; Gerardi, M; Guastella, AJ; Hendriks, G-J; Kushner, MG; Lee, FS; Lenze, EJ; Levinson, CA; McConnell, H; Plag, J; Pollack, MH; Ressler, KJ; Rodebaugh, TL; Rothbaum, BO; Storch, EA; Ströhle, A; Tart, CD; Tolin, DF; van Minnen, A; Waters, AM; Weems, CF; Wilhelm, S; Wyka, K; Altemus, M; Anderson, P; Cukor, J; Finck, C; Geffken, GR; Golfels, F; Goodman, WK; Gutner, CA; Heyman, I; Jovanovic, T; Lewin, AB; McNamara, JP; Murphy, TK; Norrholm, S; Thuras, P; Turner, C; Otto, MW, Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis, Journal of Anxiety Disorders, 2019, 68, pp. 102149: 1-102149: 8
dc.date.updated2019-11-13T04:21:47Z
gro.hasfulltextNo Full Text
gro.griffith.authorFarrell, Lara J.
gro.griffith.authorWaters, Allison M.


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