Show simple item record

dc.contributor.authorMraz, AL
dc.contributor.authorNappier, S
dc.contributor.authorHaas, CN
dc.contributor.authorWeir, MH
dc.date.accessioned2019-11-25T02:48:46Z
dc.date.available2019-11-25T02:48:46Z
dc.date.issued2019
dc.identifier.issn2352-3522
dc.identifier.doi10.1016/j.mran.2019.100087
dc.identifier.urihttp://hdl.handle.net/10072/389228
dc.description.abstractData regarding mice exposed to Eastern, Venezuelan and Western equine encephalitis viruses (EEV, VEV and WEV respectively) were used to optimize two physiologically plausible dose response models. A rich data set was extracted from an intensive literature review, with 42 independent dose groups over three exposure routes: subcutaneous, intracranial and intraperitoneal. The data demonstrate the highly infectious nature of these encephalitis viruses to a general population. However, from an examination of the data, a dependency in the dose response relationship with respect to host age is likely. This host age dependency is manifesting as an increased resistance with increased host age, conversely, higher susceptibility at lower host ages. Considering the inability to pool host age groups under a nested model, this likely host age dependency is highlighted to a greater extent. Most of the host age groups (65%) could not be used for dose-response model optimization, leaving 13 host age groups of the original 37 that could be used for optimization. Those that could be used resulted in the exponential model being the better fitting model for 61% of those data, with the approximated form of the beta Poisson being the better fitting model for the remaining five data sets.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeNetherlands
dc.relation.ispartofpagefrom100087: 1
dc.relation.ispartofpageto100087: 8
dc.relation.ispartofjournalMicrobial Risk Analysis
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchcode06
dc.titleDose response models for Eastern US, Western US and Venezuelan equine encephalitis viruses in mice – Part I: Standard dose response model and inference of host age
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMraz, AL; Nappier, S; Haas, CN; Weir, MH, Dose response models for Eastern US, Western US and Venezuelan equine encephalitis viruses in mice – Part I: Standard dose response model and inference of host age, Microbial Risk Analysis, 2019, pp. 100087: 1-100087: 8
dc.date.updated2019-11-22T03:19:44Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorWeir, Mark H.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record