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dc.contributor.authorClaytor, Sieara C
dc.contributor.authorGummer, Joel PA
dc.contributor.authorGrogan, Laura F
dc.contributor.authorSkerratt, Lee F
dc.contributor.authorWebb, Rebecca J
dc.contributor.authorBrannelly, Laura A
dc.contributor.authorBerger, Lee
dc.contributor.authorRoberts, Alexandra A
dc.date.accessioned2019-11-25T23:53:03Z
dc.date.available2019-11-25T23:53:03Z
dc.date.issued2019
dc.identifier.issn1462-5814
dc.identifier.doi10.1111/cmi.13089
dc.identifier.urihttp://hdl.handle.net/10072/389271
dc.description.abstractChytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), is a skin disease responsible for the global decline of amphibians. Frog species and populations can vary in susceptibility, but this phenomenon remains poorly understood. Here, we investigated serotonin in the skin of infected and uninfected frogs. In more susceptible frog populations, skin serotonin rose with increasing infection intensity, but decreased in later stages of the disease. The more resistant population maintained a basal level of skin serotonin. Serotonin inhibited both Bd sporangial growth and Jurkat lymphocyte proliferation in vitro. However, serotonin accumulates in skin granular glands, and this compartmentalisation may prevent inhibition of Bd growth in vivo. We suggest that skin serotonin increases in susceptible frogs due to pathogen excretion of precursor tryptophan, but that resistant frogs are able to control the levels of serotonin. Overall, the immunosuppressive effects of serotonin may contribute to the susceptibility of frogs to chytridiomycosis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley Blackwell
dc.relation.ispartofpagefrome13089:1
dc.relation.ispartofpagetoe13089:11
dc.relation.ispartofissue10
dc.relation.ispartofjournalCellular Microbiology
dc.relation.ispartofvolume21
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3207
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsCell Biology
dc.subject.keywordsBATRACHOCHYTRIUM-DENDROBATIDIS
dc.titleSusceptibility of frogs to chytridiomycosis correlates with increased levels of immunomodulatory serotonin in the skin
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationClaytor, SC; Gummer, JPA; Grogan, LF; Skerratt, LF; Webb, RJ; Brannelly, LA; Berger, L; Roberts, AA, Susceptibility of frogs to chytridiomycosis correlates with increased levels of immunomodulatory serotonin in the skin, Cellular Microbiology, 2019, 21 (10), pp. e13089:1-e13089:11
dcterms.dateAccepted2019-07-16
dc.date.updated2019-11-16T01:59:24Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2019 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Susceptibility of frogs to chytridiomycosis correlates with increased levels of immunomodulatory serotonin in the skin, Cellular Microbiology, Volume 21, Issue 10, pp e13089:1-e13089:11. , which has been published in final form at https://doi.org/10.1111/cmi.13089. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorGrogan, Laura F.


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