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  • Albicidin, a potent DNA gyrase inhibitor with clinical potential

    Author(s)
    Hashimi, Saeed Mujahid
    Griffith University Author(s)
    Hashimi, Saeed M.
    Year published
    2019
    Metadata
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    Abstract
    The emergence of multiple antibiotic-resistant bacteria is a serious global problem which requires the development of new effective antimicrobial therapeutics. Albicidin produced by the sugarcane pathogen Xanthomonas albilineans is a potent DNA gyrase inhibitor with inhibitory effects significantly better than most DNA gyrase inhibitors. Albicidin acts primarily by inhibiting the religation of the cleaved DNA intermediate during the gyrase catalytic sequence similar to quinolones. The clinical realization of albicidin has been hampered by limited production and its unsolved structure. In this review, the relationship between ...
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    The emergence of multiple antibiotic-resistant bacteria is a serious global problem which requires the development of new effective antimicrobial therapeutics. Albicidin produced by the sugarcane pathogen Xanthomonas albilineans is a potent DNA gyrase inhibitor with inhibitory effects significantly better than most DNA gyrase inhibitors. Albicidin acts primarily by inhibiting the religation of the cleaved DNA intermediate during the gyrase catalytic sequence similar to quinolones. The clinical realization of albicidin has been hampered by limited production and its unsolved structure. In this review, the relationship between albicidin and sugarcane leaf-scald disease is described. Furthermore, the biosynthesis and resistance mechanisms of albicidin are discussed. Finally, recent efforts to solve the structure and produce albicidin in a heterologous host and chemically are summarized.
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    Journal Title
    Journal of Antibiotics
    Volume
    72
    Issue
    11
    DOI
    https://doi.org/10.1038/s41429-019-0228-2
    Subject
    Microbiology
    Pharmacology and pharmaceutical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Biotechnology & Applied Microbiology
    Immunology
    Publication URI
    http://hdl.handle.net/10072/389273
    Collection
    • Journal articles

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