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dc.contributor.authorHashimi, Saeed Mujahid
dc.date.accessioned2019-11-26T03:44:31Z
dc.date.available2019-11-26T03:44:31Z
dc.date.issued2019
dc.identifier.issn0021-8820en_US
dc.identifier.doi10.1038/s41429-019-0228-2en_US
dc.identifier.urihttp://hdl.handle.net/10072/389273
dc.description.abstractThe emergence of multiple antibiotic-resistant bacteria is a serious global problem which requires the development of new effective antimicrobial therapeutics. Albicidin produced by the sugarcane pathogen Xanthomonas albilineans is a potent DNA gyrase inhibitor with inhibitory effects significantly better than most DNA gyrase inhibitors. Albicidin acts primarily by inhibiting the religation of the cleaved DNA intermediate during the gyrase catalytic sequence similar to quinolones. The clinical realization of albicidin has been hampered by limited production and its unsolved structure. In this review, the relationship between albicidin and sugarcane leaf-scald disease is described. Furthermore, the biosynthesis and resistance mechanisms of albicidin are discussed. Finally, recent efforts to solve the structure and produce albicidin in a heterologous host and chemically are summarized.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherNature Publishing Groupen_US
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom785en_US
dc.relation.ispartofpageto792en_US
dc.relation.ispartofissue11en_US
dc.relation.ispartofjournalJournal of Antibioticsen_US
dc.relation.ispartofvolume72en_US
dc.subject.fieldofresearchMicrobiologyen_US
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciencesen_US
dc.subject.fieldofresearchcode0605en_US
dc.subject.fieldofresearchcode1115en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsBiotechnology & Applied Microbiologyen_US
dc.subject.keywordsImmunologyen_US
dc.titleAlbicidin, a potent DNA gyrase inhibitor with clinical potentialen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationHashimi, SM, Albicidin, a potent DNA gyrase inhibitor with clinical potential, Journal of Antibiotics, 2019, 72 (11), pp. 785-792en_US
dcterms.dateAccepted2019-08-14
dc.date.updated2019-11-26T00:26:04Z
gro.hasfulltextNo Full Text
gro.griffith.authorHashimi, Saeed M.


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