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  • Acute but not chronic caffeine impairs functional responses to ischaemia-reperfusion in rat isolated perfused heart.

    Author(s)
    Rose'Meyer, RB
    Headrick, JP
    Peart, JN
    Harrison, GJ
    Garnham, BG
    Willis, RJ
    Griffith University Author(s)
    Willis, Roger J.
    Harrison, Glenn J.
    Peart, Jason N.
    Rose'Meyer, Roselyn B.
    Year published
    2001
    Metadata
    Show full item record
    Abstract
    1. The effect of acute (50 孯l/L) and chronic (0.06% in drinking water for 14 days) caffeine on the response to ischaemia-reperfusion was studied in Wistar rat isolated perfused hearts. 2. Neither acute nor chronic caffeine modified normoxic heart rate or left ventricular pressures. However, acute caffeine decreased coronary flow by up to 20%, while chronic caffeine consumption increased coronary flow by approximately 15% and abolished the vasoconstrictor effect of acute caffeine (P< 0.05). 3. After 15 min global ischaemia, chronic caffeine treatment did not alter the recovery of left ventricular diastolic pressure ...
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    1. The effect of acute (50 孯l/L) and chronic (0.06% in drinking water for 14 days) caffeine on the response to ischaemia-reperfusion was studied in Wistar rat isolated perfused hearts. 2. Neither acute nor chronic caffeine modified normoxic heart rate or left ventricular pressures. However, acute caffeine decreased coronary flow by up to 20%, while chronic caffeine consumption increased coronary flow by approximately 15% and abolished the vasoconstrictor effect of acute caffeine (P< 0.05). 3. After 15 min global ischaemia, chronic caffeine treatment did not alter the recovery of left ventricular diastolic pressure (LVDP), end-diastolic pressure (EDP) or heart rate during reperfusion, but did enhance coronary flow rate (P< 0.05). Acute caffeine inhibited the recovery of LVDP and elevated postischaemic EDP in both caffeine-naﶥ and chronic caffeine-treated groups. Acute caffeine also significantly inhibited coronary reflow in naﶥ but not chronic caffeine-treated groups and produced a transient tachycardia during reperfusion in hearts from chronic caffeine-treated rats. 4. The incidence of arrhythmias was unaltered by chronic caffeine treatment, but was increased by acute caffeine in both naﶥ and chronic caffeine hearts. 5. In conclusion, chronic caffeine intake alone has no detrimental effects on recovery from ischaemia; however, acute caffeine worsens postischaemic contractile function in hearts from naﶥ and chronic caffeine-treated rats.
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    Journal Title
    Clinical and Experimental Pharmacology & Physiology
    Volume
    28
    Publisher URI
    http://www.blackwell-synergy.com/doi/full/10.1046/j.1440-1681.2001.03389.x
    DOI
    https://doi.org/10.1046/j.1440-1681.2001.03389.x
    Copyright Statement
    © 2001 Blackwell Publishing. The definitive version is available at [www.blackwell-synergy.com.]
    Subject
    Zoology
    Pharmacology and pharmaceutical sciences
    Medical physiology
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/3893
    Collection
    • Journal articles

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