Hepatocellular carcinoma in older adults: A comprehensive review by Young International Society of Geriatric Oncology

Author(s)
Arora, Sukeshi Patel
Liposits, Gabor
Caird, Susan
Dunne, Richard F
Moffat, Gordon Taylor
Okonji, David
Rodriquenz, Maria Grazia
Dua, Divyanshu
Dotan, Efrat
Griffith University Author(s)
Year published
2019
Metadata
Show full item recordAbstract
Given the prevalence and the rising incidence of hepatocellular carcinoma (HCC) in older adults worldwide, there is an urgent need to improve our understanding of the implications of treatment modalities in this population. The care of older patients with HCC is challenging due to the lack of evidence-based recommendations in this population. The current treatment approach for older patients relies on extrapolation of data from clinical trials conducted mostly in younger patients or fit older adults. Further, in the last few years, the arsenal of systemic treatments has increased with currently seven FDA-approved therapies ...
View more >Given the prevalence and the rising incidence of hepatocellular carcinoma (HCC) in older adults worldwide, there is an urgent need to improve our understanding of the implications of treatment modalities in this population. The care of older patients with HCC is challenging due to the lack of evidence-based recommendations in this population. The current treatment approach for older patients relies on extrapolation of data from clinical trials conducted mostly in younger patients or fit older adults. Further, in the last few years, the arsenal of systemic treatments has increased with currently seven FDA-approved therapies available for patients with advanced HCC. Therefore, understanding how to apply current data to this unique and diverse patient population is necessary. This review will aim to shed light on the approach to older adults with HCC through an assessment of available data in the literature.
View less >
View more >Given the prevalence and the rising incidence of hepatocellular carcinoma (HCC) in older adults worldwide, there is an urgent need to improve our understanding of the implications of treatment modalities in this population. The care of older patients with HCC is challenging due to the lack of evidence-based recommendations in this population. The current treatment approach for older patients relies on extrapolation of data from clinical trials conducted mostly in younger patients or fit older adults. Further, in the last few years, the arsenal of systemic treatments has increased with currently seven FDA-approved therapies available for patients with advanced HCC. Therefore, understanding how to apply current data to this unique and diverse patient population is necessary. This review will aim to shed light on the approach to older adults with HCC through an assessment of available data in the literature.
View less >
Journal Title
Journal of Geriatric Oncology
Note
This publication has been entered into Griffith Research Online as an Advanced Online Version
Subject
Oncology and carcinogenesis
Geriatric assessment
Hepatocellular carcinoma
Multimodality treatment
Older adult
Geriatric assessment