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dc.contributor.authorPrimiero, CA
dc.contributor.authorMcInerney-Leo, AM
dc.contributor.authorBetz-Stablein, B
dc.contributor.authorWhiteman, DC
dc.contributor.authorGordon, L
dc.contributor.authorCaffery, L
dc.contributor.authorAitken, JF
dc.contributor.authorEakin, E
dc.contributor.authorOsborne, S
dc.contributor.authorGray, L
dc.contributor.authorSmithers, BM
dc.contributor.authorJanda, M
dc.contributor.authorSoyer, HP
dc.contributor.authorFinnane, A
dc.date.accessioned2019-11-29T01:07:03Z
dc.date.available2019-11-29T01:07:03Z
dc.date.issued2019
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2019-032969
dc.identifier.urihttp://hdl.handle.net/10072/389381
dc.description.abstractIntroduction Melanoma is Australia's fourth most common cancer. Early detection is fundamental in maximising health outcomes and minimising treatment costs. To date, population-based screening programmes have not been justified in health economic studies. However, a skin surveillance approach targeting high-risk individuals could improve the cost-benefit ratio. Methods and analysis This paper describes a 2-year longitudinal randomised controlled trial (RCT) to compare routine clinical care (control) with an intensive skin surveillance programme (intervention) consisting of novel three-dimensional (3D) total-body photography (TBP), sequential digital dermoscopy and melanoma-risk stratification, in a high-risk melanoma cohort. Primary outcomes will evaluate clinical, economic and consumer impact of the intervention. Clinical outcomes will evaluate differences in the rate of lesion excisions/biopsies per person, benign to malignant ratio for excisions and thickness of melanomas diagnosed. A health economic analysis using government data repositories will capture healthcare utilisation and costs relating to skin surveillance. Consumer questionnaires will examine intervention acceptability, the psychological impact, and attitudes towards melanoma risk and sun protective behaviour. Secondary outcomes include the development of a holistic risk algorithm incorporating clinical, phenotypic and genetic factors to facilitate the identification of those most likely to benefit from this surveillance approach. Furthermore, the feasibility of integrating the intervention with teledermatology to enhance specialist care in remote locations will be evaluated. This will be the first RCT to compare a targeted surveillance programme utilising new 3D TBP technology against current routine clinical care for individuals at high risk of melanoma. Ethics and dissemination This study has received Human Research Ethics Committee (HREC) approval from both Metro South Health HREC (HREC/17/QPAH/816) and The University of Queensland HREC (2018000074). Trial registration number ANZCTR12618000267257; Pre-results.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherB M J Group
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrome032969: 1
dc.relation.ispartofpagetoe032969: 9
dc.relation.ispartofissue11
dc.relation.ispartofjournalBMJ Open
dc.relation.ispartofvolume9
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchOther Medical and Health Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1117
dc.subject.fieldofresearchcode1199
dc.subject.keywordsRCT
dc.subject.keywordsearly detection
dc.subject.keywordsmelanoma
dc.subject.keywordstotal-body photography
dc.titleEvaluation of the efficacy of 3D total-body photography with sequential digital dermoscopy in a high-risk melanoma cohort: Protocol for a randomised controlled trial
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationPrimiero, CA; McInerney-Leo, AM; Betz-Stablein, B; Whiteman, DC; Gordon, L; Caffery, L; Aitken, JF; Eakin, E; Osborne, S; Gray, L; Smithers, BM; Janda, M; Soyer, HP; Finnane, A, Evaluation of the efficacy of 3D total-body photography with sequential digital dermoscopy in a high-risk melanoma cohort: Protocol for a randomised controlled trial, BMJ Open, 2019, 9 (11), pp. e032969: 1-e032969: 9
dcterms.licensehttps://creativecommons.org/licenses/by-nc/4.0/
dc.date.updated2019-11-27T02:58:44Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Author(s) 2019. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
gro.hasfulltextNo Full Text
gro.griffith.authorAitken, Joanne
gro.griffith.authorJanda, Monika


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