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dc.contributor.authorVukotic, Marina
dc.contributor.authorSingh, Indu
dc.contributor.authorKundur, Avinash
dc.date.accessioned2019-12-05T00:58:21Z
dc.date.available2019-12-05T00:58:21Z
dc.date.issued2018
dc.identifier.issn0972-4567
dc.identifier.urihttp://hdl.handle.net/10072/389388
dc.description.abstractAutoimmune diseases are a broad class of disorders that are characterised by the irregular response of immune cells creating self-reactive antibodies that target its own cells and tissues. The primary cause for the development of autoimmunity is yet to be known. However, current research suggests that increased genetic susceptibility combined with multitude of triggering elements such as environmental influences and infection are some of the most significant causative factors leading to autoimmunity. Using the above-mentioned factors, till date, researchers have proposed several theories in an attempt to explain the underlying mechanisms and complexities of how autoimmunity occurs. Some of the most widely accepted theories include cryptic determinants, molecular mimicry, altered glycan theory, and the hygiene hypothesis as well as the interaction of B and T lymphocytic cells. Understanding these molecular mechanisms of autoimmune diseases is key for the development of future preventative therapies, as currently there is no therapeutic strategy to cure these conditions. The traditional concept of T cell-mediated and autoantibody-mediated autoimmune diseases should be adjusted to reflect the new understanding of the interaction of different immune cells in autoimmune pathogenesis. Recognition of B cell contribution to the pathogenesis of autoimmune diseases (traditionally thought to be mediated by T cells) has led to promising new therapies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherResearch Trends
dc.publisher.placeIndia
dc.publisher.urihttp://www.researchtrends.net/tia/abstract.asp?in=0&vn=19&tid=36&aid=6204&pub=2018&type=3
dc.relation.ispartofpagefrom23
dc.relation.ispartofpageto32
dc.relation.ispartofjournalCurrent Trends in Immunology
dc.relation.ispartofvolume19
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode1107
dc.titleAutoimmune diseases: Understanding the mechanisms and therapeutic strategies for treating autoimmunity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationVukotic, M; Singh, I; Kundur, A, Autoimmune diseases: Understanding the mechanisms and therapeutic strategies for treating autoimmunity, Current Trends in Immunology, 2018, 19, pp. 23-32
dc.date.updated2019-11-26T00:01:57Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2018 Research Trends. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorKundur, Avinash R.
gro.griffith.authorSingh, Indu
gro.griffith.authorVukotic, Marina


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