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dc.contributor.authorMarx, Wolfgang
dc.contributor.authorTeleni, Laisa
dc.contributor.authorOpie, Rachelle S
dc.contributor.authorKelly, Jaimon
dc.contributor.authorMarshall, Skye
dc.contributor.authorItsiopoulos, Catherine
dc.contributor.authorIsenring, Elizabeth
dc.date.accessioned2019-12-04T00:30:15Z
dc.date.available2019-12-04T00:30:15Z
dc.date.issued2017
dc.identifier.issn2072-6643
dc.identifier.doi10.3390/nu9111224
dc.identifier.urihttp://hdl.handle.net/10072/389472
dc.description.abstractBackground: Carnitine deficiency has been implicated as a potential pathway for cancer-related fatigue that could be treated with carnitine supplementation. The aim of this systematic literature review and meta-analysis was to evaluate the literature regarding the use of supplemental carnitine as a treatment for cancer-related fatigue. Methods: Using the PRISMA guidelines, an electronic search of the Cochrane Library, MEDLINE, Embase, CINAHL and reference lists was conducted. Data were extracted and independently assessed for quality using the Academy of Nutrition and Dietetics evidence analysis by two reviewers. In studies with positive quality ratings, a meta-analysis was performed using the random-effects model on Carnitine and cancer-related fatigue. Results: Twelve studies were included for review with eight reporting improvement in measures of fatigue, while four reported no benefit. However, many studies were non-randomized, open-label and/or used inappropriate dose or comparators. Meta-analysis was performed in three studies with sufficient data. Carnitine did not significantly reduce cancer-related fatigue with a standardized mean difference (SMD) of 0.06 points ((95% CI −0.09, 0.21); p = 0.45). Conclusion: Results from studies with lower risk of bias do not support the use of carnitine supplementation for cancer-related fatigue.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMDPI AG
dc.publisher.placeSwitzerland
dc.relation.ispartofpagefrom1224: 1
dc.relation.ispartofpageto1224: 24
dc.relation.ispartofissue11
dc.relation.ispartofjournalNutrients
dc.relation.ispartofvolume9
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchFood Sciences
dc.subject.fieldofresearchNutrition and Dietetics
dc.subject.fieldofresearchcode1112
dc.subject.fieldofresearchcode0908
dc.subject.fieldofresearchcode1111
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsNutrition & Dietetics
dc.subject.keywordscarnitine
dc.subject.keywordsfatigue
dc.titleEfficacy and Effectiveness of Carnitine Supplementation for Cancer-Related Fatigue: A Systematic Literature Review and Meta-Analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMarx, W; Teleni, L; Opie, RS; Kelly, J; Marshall, S; Itsiopoulos, C; Isenring, E, Efficacy and Effectiveness of Carnitine Supplementation for Cancer-Related Fatigue: A Systematic Literature Review and Meta-Analysis, Nutrients, 2017, 9 (11), pp. 1224: 1-1224: 24
dcterms.dateAccepted2017-11-03
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-12-02T23:29:04Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
gro.hasfulltextFull Text
gro.griffith.authorKelly, Jaimon


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