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dc.contributor.authorCristino, Alexandre
dc.contributor.authorNascimento, AM
dc.contributor.authorCosta, L da F
dc.contributor.authorSimoes, ZL
dc.date.accessioned2019-12-04T01:34:29Z
dc.date.available2019-12-04T01:34:29Z
dc.date.issued2019
dc.identifier.issn1676-5680
dc.identifier.urihttp://hdl.handle.net/10072/389480
dc.description.abstractABSTRACT A comparison of the most conserved sex-determining genes between the fruit fly, Drosophila melanogaster, and the honey bee, Apis mellifera, was performed with bioinformatics tools developed for computational molecular biology. An initial set of protein sequences already described in the fruit fly as participants of the sex-determining cascade was retrieved from the Gene Ontology database (http://www.geneontology.org/) and aligned against a database of protein sequences predicted from the honey bee genome. The doublesex (dsx) gene is considered one of the most conserved sex-determining genes among metazoans, and a male-specific partial cDNA of putative A. mellifera dsx gene (Amdsx) was identified experimentally. The theoretical predictions were developed in the context of sequence similarity. Experimental evidence indicates that dsx is present in embryos and larvae, and that it encodes a transcription factor widely conserved in metazoans, containing a DM DNA-binding domain implicated in the regulation of the expression of genes involved in sexual phenotype formation. A comparison of the most conserved sex-determining genes between the fruit fly, Drosophila melanogaster, and the honey bee, Apis mellifera, was performed with bioinformatics tools developed for computational molecular biology. An initial set of protein sequences already described in the fruit fly as participants of the sex-determining cascade was retrieved from the Gene Ontology database (http://www.geneontology.org/) and aligned against a database of protein sequences predicted from the honey bee genome. The doublesex (dsx) gene is considered one of the most conserved sex-determining genes among metazoans, and a male-specific partial cDNA of putative A. mellifera dsx gene (Amdsx) was identified experimentally. The theoretical predictions were developed in the context of sequence similarity. Experimental evidence indicates that dsx is present in embryos and larvae, and that it encodes a transcription factor widely conserved in metazoans, containing a DM DNA-binding domain implicated in the regulation of the expression of genes involved in sexual phenotype formation.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFundacao de Pesquisas Cientificas de Ribeirao Preto
dc.publisher.urihttps://www.geneticsmr.com/articles/254
dc.relation.ispartofpagefrom154
dc.relation.ispartofpageto168
dc.relation.ispartofissue1
dc.relation.ispartofjournalGenetics and Molecular Research
dc.relation.ispartofvolume5
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode0604
dc.subject.keywordsMolecular Biology
dc.titleA comparative analysis of highly conserved sex-determining genes between Apis mellifera and Drosophila melanogaster.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCristino, A; Nascimento, AM; Costa, LDF; Simoes, ZL, A comparative analysis of highly conserved sex-determining genes between Apis mellifera and Drosophila melanogaster., Genetics and Molecular Research, 2006, 5 (1), pp. 154-168
dcterms.licensehttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.date.updated2019-12-03T07:45:55Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2006. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. If you alter, transform, or build upon this work, you may distribute the resulting work only under a licence identical to this one.
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gro.griffith.authorCristino, Alex


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