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dc.contributor.authorRautenberg, Tamlyn
dc.contributor.authorZerwes, Ute
dc.date.accessioned2019-12-04T02:16:32Z
dc.date.available2019-12-04T02:16:32Z
dc.date.issued2017
dc.identifier.issn1178-6981en_US
dc.identifier.doi10.2147/ceor.s140902en_US
dc.identifier.urihttp://hdl.handle.net/10072/389484
dc.description.abstractObjective: To evaluate the cost utility and the budget impact of adjuvant racecadotril for the treatment of acute diarrhea in children in Thailand. Methods: A cost utility model has been adapted to the context of Thailand to evaluate racecadotril plus oral rehydration solution (R+ORS) versus oral rehydration solution (ORS) alone for acute diarrhea in children <5 years old. The decision tree Excel model evaluates the costs and effects (quality-adjusted life years) over a 6-day time horizon from a public health care payer’s perspective in Thailand. Deterministic sensitivity analysis and budget impact analysis have been undertaken. Results: According to the cost utility model, the intervention (R+ORS) is less costly and more effective than the comparator (ORS) for the base case with a dominant incremental cost-effectiveness ratio of −2,481,390฿ for the intervention. According to the budget impact analysis (assuming an increase of 5% market share for R+ORS over 5 years), the year-on-year reduction for diarrhea as a percentage of the total health care expenditure is −0.0027%, resulting in potential net cost savings of −35,632,482฿ over 5 years. Conclusion: Subject to the assumptions and limitations of the models, adjuvant racecadotril versus ORS alone is potentially cost-effective for children in Thailand and uptake could translate into savings for the Thailand public health care system.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherDove Medical Pressen_US
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom411en_US
dc.relation.ispartofpageto422en_US
dc.relation.ispartofjournalClinicoEconomics and Outcomes Researchen_US
dc.relation.ispartofvolume9en_US
dc.subject.fieldofresearchPublic Health and Health Servicesen_US
dc.subject.fieldofresearchcode1117en_US
dc.titleThe cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailanden_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationRautenberg, T; Zerwes, U, The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand, ClinicoEconomics and Outcomes Research, 2017, 9, pp. 411-422en_US
dcterms.licensehttp://creativecommons.org/licenses/by-nc/3.0/en_US
dc.date.updated2019-12-03T03:57:28Z
dc.description.versionPublisheden_US
gro.rights.copyright© 2017 Rautenberg and Zerwes. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).en_US
gro.hasfulltextFull Text
gro.griffith.authorRautenberg, Tamlyn


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