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dc.contributor.authorWong, Ximena
dc.contributor.authorCarrasco-Pozo, Catalina
dc.contributor.authorEscobar, Elizabeth
dc.contributor.authorNavarrete, Paola
dc.contributor.authorBlachier, Francois
dc.contributor.authorAndriamihaja, Mireille
dc.contributor.authorLang, Annaig
dc.contributor.authorTome, Daniel
dc.contributor.authorJose Cires, Maria
dc.contributor.authorPastene, Edgar
dc.contributor.authorGotteland, Martin
dc.date.accessioned2019-12-05T01:20:07Z
dc.date.available2019-12-05T01:20:07Z
dc.date.issued2016
dc.identifier.issn0021-8561
dc.identifier.doi10.1021/acs.jafc.6b00656
dc.identifier.urihttp://hdl.handle.net/10072/389509
dc.description.abstractThe protective effect of proanthocyanidin-containing polyphenol extracts from apples, avocados, cranberries, grapes, or proanthocyanidin microbial metabolites was evaluated in colonic epithelial cells exposed to p-cresol, a deleterious compound produced by the colonic microbiota from l-tyrosine. In HT29 Glc-/+ cells, p-cresol significantly increased LDH leakage and decreased ATP contents, whereas in Caco-2 cell monolayers, it significantly decreased the transepithelial electrical resistance and increased the paracellular transport of FITC-dextran. The alterations induced by p-cresol in HT29 Glc-/+ cells were prevented by the extracts from cranberries and avocados, whereas they became worse by extracts from apples and grapes. The proanthocyanidin bacterial metabolites decreased LDH leakage, ameliorating cell viability without improving intracellular ATP. All of the polyphenol extracts and proanthocyanidin bacterial metabolites prevented the p-cresol-induced alterations of barrier function. These results suggest that proanthocyanidin-containing polyphenol extracts and proanthocyanidin metabolites likely contribute to the protection of the colonic mucosa against the deleterious effects of p-cresol.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherAMER CHEMICAL SOC
dc.relation.ispartofpagefrom3574
dc.relation.ispartofpageto3583
dc.relation.ispartofissue18
dc.relation.ispartofjournalJournal of Agricultural and Food Chemistry
dc.relation.ispartofvolume64
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode09
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsAgriculture, Multidisciplinary
dc.subject.keywordsChemistry, Applied
dc.titleDeleterious Effect of p-Cresol on Human Colonic Epithelial Cells Prevented by Proanthocyanidin-Containing Polyphenol Extracts from Fruits and Proanthocyanidin Bacterial Metabolites
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWong, X; Carrasco-Pozo, C; Escobar, E; Navarrete, P; Blachier, F; Andriamihaja, M; Lang, A; Tome, D; Jose Cires, M; Pastene, E; Gotteland, M, Deleterious Effect of p-Cresol on Human Colonic Epithelial Cells Prevented by Proanthocyanidin-Containing Polyphenol Extracts from Fruits and Proanthocyanidin Bacterial Metabolites, Journal of Agricultural and Food Chemistry, 2016, 64 (18), pp. 3574-3583
dc.date.updated2019-12-05T00:22:03Z
dc.description.versionPost-print
gro.rights.copyrightThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry, copyright 2016 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.jafc.6b00656
gro.hasfulltextFull Text
gro.griffith.authorCarrasco Pozo, Catalina A.


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