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  • Polyphenol extracts interfere with bacterial lipopolysaccharide in vitro and decrease postprandial endotoxemia in human volunteers

    Author(s)
    Wong, Ximena
    Maria Madrid, Ana
    Tralma, Karina
    Castillo, Romina
    Carrasco-Pozo, Catalina
    Navarrete, Paola
    Beltran, Caroll
    Pastene, Edgar
    Gotteland, Martin
    Griffith University Author(s)
    Carrasco Pozo, Catalina A.
    Year published
    2016
    Metadata
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    Abstract
    The intestinal absorption of bacterial lipopolysaccharide (LPS) and dietary fat has been implicated in the development of metabolic endotoxemia. This study first compared the ability of polyphenol extracts from grape, cranberry, avocado and apple to interfere with pancreatic lipase and LPS in vitro. The grape extract displayed a higher inhibitory activity of lipase (IC50 = 8.6 ± 1.1 mg/ml) and LPS binding (IC50 = 90 ± 1.1 µg/ml). Then, a study was carried out in 12 normal weight and 17 overweight/obese subjects to determine the effect of this extract on the postprandial changes in plasma triacylglycerols, LPS and IL-6. The ...
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    The intestinal absorption of bacterial lipopolysaccharide (LPS) and dietary fat has been implicated in the development of metabolic endotoxemia. This study first compared the ability of polyphenol extracts from grape, cranberry, avocado and apple to interfere with pancreatic lipase and LPS in vitro. The grape extract displayed a higher inhibitory activity of lipase (IC50 = 8.6 ± 1.1 mg/ml) and LPS binding (IC50 = 90 ± 1.1 µg/ml). Then, a study was carried out in 12 normal weight and 17 overweight/obese subjects to determine the effect of this extract on the postprandial changes in plasma triacylglycerols, LPS and IL-6. The presence of small intestine bacterial overgrowth (SIBO), in which higher levels of bacteria and eventually LPS are present in the upper intestine, i.e. where dietary fat absorption occurs, was also evaluated. Compared with placebo, the grape extract did not affect postprandial triacylglycerolemia but decreased plasma LPS, without affecting the IL-6-associated inflammatory response. SIBO did not affect these variables.
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    Journal Title
    Journal of Functional Foods
    Volume
    26
    DOI
    https://doi.org/10.1016/j.jff.2016.08.011
    Subject
    Food sciences
    Nutrition and dietetics
    Medical physiology
    Science & Technology
    Life Sciences & Biomedicine
    Proanthocyanidins
    Publication URI
    http://hdl.handle.net/10072/389511
    Collection
    • Journal articles

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