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dc.contributor.authorWong, Ximena
dc.contributor.authorMaria Madrid, Ana
dc.contributor.authorTralma, Karina
dc.contributor.authorCastillo, Romina
dc.contributor.authorCarrasco-Pozo, Catalina
dc.contributor.authorNavarrete, Paola
dc.contributor.authorBeltran, Caroll
dc.contributor.authorPastene, Edgar
dc.contributor.authorGotteland, Martin
dc.date.accessioned2019-12-05T01:33:28Z
dc.date.available2019-12-05T01:33:28Z
dc.date.issued2016
dc.identifier.issn1756-4646
dc.identifier.doi10.1016/j.jff.2016.08.011
dc.identifier.urihttp://hdl.handle.net/10072/389511
dc.description.abstractThe intestinal absorption of bacterial lipopolysaccharide (LPS) and dietary fat has been implicated in the development of metabolic endotoxemia. This study first compared the ability of polyphenol extracts from grape, cranberry, avocado and apple to interfere with pancreatic lipase and LPS in vitro. The grape extract displayed a higher inhibitory activity of lipase (IC50 = 8.6 ± 1.1 mg/ml) and LPS binding (IC50 = 90 ± 1.1 µg/ml). Then, a study was carried out in 12 normal weight and 17 overweight/obese subjects to determine the effect of this extract on the postprandial changes in plasma triacylglycerols, LPS and IL-6. The presence of small intestine bacterial overgrowth (SIBO), in which higher levels of bacteria and eventually LPS are present in the upper intestine, i.e. where dietary fat absorption occurs, was also evaluated. Compared with placebo, the grape extract did not affect postprandial triacylglycerolemia but decreased plasma LPS, without affecting the IL-6-associated inflammatory response. SIBO did not affect these variables.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom406
dc.relation.ispartofpageto417
dc.relation.ispartofjournalJournal of Functional Foods
dc.relation.ispartofvolume26
dc.subject.fieldofresearchFood sciences
dc.subject.fieldofresearchNutrition and dietetics
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3006
dc.subject.fieldofresearchcode3210
dc.subject.fieldofresearchcode3208
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsProanthocyanidins
dc.titlePolyphenol extracts interfere with bacterial lipopolysaccharide in vitro and decrease postprandial endotoxemia in human volunteers
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationWong, X; Maria Madrid, A; Tralma, K; Castillo, R; Carrasco-Pozo, C; Navarrete, P; Beltran, C; Pastene, E; Gotteland, M, Polyphenol extracts interfere with bacterial lipopolysaccharide in vitro and decrease postprandial endotoxemia in human volunteers, Journal of Functional Foods, 2016, 26, pp. 406-417
dc.date.updated2019-12-05T00:27:15Z
gro.hasfulltextNo Full Text
gro.griffith.authorCarrasco Pozo, Catalina A.


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