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dc.contributor.authorCarrasco-Pozo, Catalina
dc.contributor.authorSpeisky, Hernan
dc.contributor.authorBrunser, Oscar
dc.contributor.authorPastene, Edgar
dc.contributor.authorGotteland, Martin
dc.date.accessioned2019-12-05T04:07:16Z
dc.date.available2019-12-05T04:07:16Z
dc.date.issued2011
dc.identifier.issn0021-8561
dc.identifier.doi10.1021/jf200553s
dc.identifier.urihttp://hdl.handle.net/10072/389531
dc.description.abstractThe stability of an apple peel polyphenol extract (APPE) with powerful antioxidant activity was evaluated under acidic conditions in vitro, and its protective effect against gastrointestinal damage was investigated in rats treated with indomethacin. The antioxidant activity of APPE remained stable at pH 2.0 for 4 h. In rats treated with indomethacin (40 mg/kg ig), the previous administration of APPE protected the gastric, intestinal, and colonic mucosa from oxidative stress by preventing increased malondialdehyde concentrations and decreasing the GSH/GSSG ratio. APPE also displayed anti-inflammatory effects by preventing neutrophil infiltration in the mucosa, as evidenced by the lower myeloperoxidase activity. These protective effects of APPE resulted in the prevention of macro- and microscopic damage and of barrier dysfunction along the gastrointestinal tract of the indomethacin-treated animals. This study supports the concept that apple peel polyphenols may be useful in the prevention and/or treatment of nonsteroidal anti-inflammatory drug-associated side effects. © 2011 American Chemical Society.
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS Publications)
dc.relation.ispartofpagefrom6459
dc.relation.ispartofpageto6466
dc.relation.ispartofissue12
dc.relation.ispartofjournalJournal of Agricultural and Food Chemistry
dc.relation.ispartofvolume59
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode40
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsAgriculture, Multidisciplinary
dc.subject.keywordsChemistry, Applied
dc.titleApple Peel Polyphenols Protect against Gastrointestinal Mucosa Alterations Induced by Indomethacin in Rats
dc.typeJournal article
dcterms.bibliographicCitationCarrasco-Pozo, C; Speisky, H; Brunser, O; Pastene, E; Gotteland, M, Apple Peel Polyphenols Protect against Gastrointestinal Mucosa Alterations Induced by Indomethacin in Rats, Journal of Agricultural and Food Chemistry, 2011, 59 (12), pp. 6459-6466
dc.date.updated2019-12-05T00:51:29Z
gro.hasfulltextNo Full Text
gro.griffith.authorCarrasco Pozo, Catalina A.


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