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dc.contributor.authorCarrasco-Pozo, Catalina
dc.contributor.authorMorales, Pamela
dc.contributor.authorGotteland, Martin
dc.date.accessioned2019-12-05T04:49:45Z
dc.date.available2019-12-05T04:49:45Z
dc.date.issued2013
dc.identifier.issn0021-8561
dc.identifier.doi10.1021/jf400150p
dc.identifier.urihttp://hdl.handle.net/10072/389539
dc.description.abstractThe aim of this study was to determine the protective effect of quercetin, epigallocatechingallate, resveratrol, and rutin against the disruption of epithelial integrity induced by indomethacin in Caco-2 cell monolayers. Indomethacin decreased the transepithelial electrical resistance and increased the permeability of the monolayers to fluorescein-dextran. These alterations were abolished by all the tested polyphenols but rutin, with quercetin being the most efficient. The protective effect of quercetin was associated with its capacity to inhibit the redistribution of ZO-1 protein induced in the tight junction by indomethacin or rotenone, a mitochondrial complex-I inhibitor, and to prevent the decrease of ZO-1 and occludin expression induced by indomethacin. The fact that the antioxidant polyphenols assayed in this study differ in their protective capacity against the epithelial damage induced by indomethacin suggests that this damage is due to the ability of this agent to induce not only oxidative stress but also mitochondrial dysfunction.
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS Publications)
dc.relation.ispartofpagefrom5291
dc.relation.ispartofpageto5297
dc.relation.ispartofissue22
dc.relation.ispartofjournalJournal of Agricultural and Food Chemistry
dc.relation.ispartofvolume61
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchEngineering
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode40
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsPhysical Sciences
dc.subject.keywordsAgriculture, Multidisciplinary
dc.subject.keywordsChemistry, Applied
dc.titlePolyphenols Protect the Epithelial Barrier Function of Caco-2 Cells Exposed to Indomethacin through the Modulation of Occludin and Zonula Occludens-1 Expression
dc.typeJournal article
dcterms.bibliographicCitationCarrasco-Pozo, C; Morales, P; Gotteland, M, Polyphenols Protect the Epithelial Barrier Function of Caco-2 Cells Exposed to Indomethacin through the Modulation of Occludin and Zonula Occludens-1 Expression, Journal of Agricultural and Food Chemistry, 2013, 61 (22), pp. 5291-5297
dc.date.updated2019-12-05T01:04:23Z
gro.hasfulltextNo Full Text
gro.griffith.authorCarrasco Pozo, Catalina A.


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