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dc.contributor.authorReyes-Farias, M
dc.contributor.authorCarrasco-Pozo, C
dc.date.accessioned2019-12-05T23:12:31Z
dc.date.available2019-12-05T23:12:31Z
dc.date.issued2019
dc.identifier.issn1661-6596
dc.identifier.doi10.3390/ijms20133177
dc.identifier.urihttp://hdl.handle.net/10072/389553
dc.description.abstractCancer is a problem with worldwide importance and is the second leading cause of death globally. Cancer cells reprogram their metabolism to support their uncontrolled expansion by increasing biomass (anabolic metabolism—glycolysis) at the expense of their energy (bioenergetics-mitochondrial function) requirements. In this aspect, metabolic reprogramming stands out as a key biological process in understanding the conversion of a normal cell into a neoplastic precursor. Quercetin is the major representative of the flavonoid subclass of flavonols. Quercetin is ubiquitously present in fruits and vegetables, being one of the most common dietary flavonols in the western diet. The anti-cancer effects of quercetin include its ability to promote the loss of cell viability, apoptosis and autophagy through the modulation of PI3K/Akt/mTOR, Wnt/β-catenin, and MAPK/ERK1/2 pathways. In this review, we discuss the role of quercetin in cancer metabolism, addressing specifically its ability to target molecular pathways involved in glucose metabolism and mitochondrial function.
dc.languageeng
dc.relation.ispartofpagefrom3177:1
dc.relation.ispartofpageto3177:19
dc.relation.ispartofissue13
dc.relation.ispartofjournalInternational Journal of Molecular Sciences
dc.relation.ispartofvolume20
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchOther Biological Sciences
dc.subject.fieldofresearchcode0399
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0699
dc.subject.keywordsPI3K/Akt pathway
dc.subject.keywordscancer
dc.subject.keywordsglycolysis
dc.subject.keywordsmitochondrial function
dc.subject.keywordsquercetin
dc.titleThe anti-cancer effect of quercetin: Molecular implications in cancer metabolism
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationReyes-Farias, M; Carrasco-Pozo, C, The anti-cancer effect of quercetin: Molecular implications in cancer metabolism, International Journal of Molecular Sciences, 2019, 20 (13), pp. 3177:1-3177:19
dcterms.dateAccepted2019-06-25
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-12-05T00:03:45Z
dc.description.versionPublished
gro.rights.copyright© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
gro.hasfulltextFull Text
gro.griffith.authorCarrasco Pozo, Catalina A.


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