Olfactory Ensheathing Cell Behaviour and Interactions are Modulated by Secreted Products of OECs
Author(s)
Primary Supervisor
Ekberg, Jenny A.
Other Supervisors
St John, James A.
Todorovic, Michael
Fex-Svenningsen, Asa
Year published
2019-11
Metadata
Show full item recordAbstract
The work presented in this thesis demonstrates that (1) the neurotrophins NGF and BDNF, which are secreted from OECs, significantly increase OEC proliferation, migration and phagocytosis; (2) OECs in vivo and in culture express the cytokine MIF (shown through immunolabelling, genetic expression and functional assays), and MIF stimulates OEC phagocytosis; (3) MIF is responsible for the segregation of OECs and macrophages in a model of the olfactory nerve as shown by their subsequent mingling upon MIF inhibition. The results here lend evidence that these proteins, which are secreted by OECs, may play a combinatorial role in ...
View more >The work presented in this thesis demonstrates that (1) the neurotrophins NGF and BDNF, which are secreted from OECs, significantly increase OEC proliferation, migration and phagocytosis; (2) OECs in vivo and in culture express the cytokine MIF (shown through immunolabelling, genetic expression and functional assays), and MIF stimulates OEC phagocytosis; (3) MIF is responsible for the segregation of OECs and macrophages in a model of the olfactory nerve as shown by their subsequent mingling upon MIF inhibition. The results here lend evidence that these proteins, which are secreted by OECs, may play a combinatorial role in the olfactory system’s regenerative potential and as such provide direction towards improving the therapeutic potential of OEC transplantation to treat SCI and other nervous system injuries.
View less >
View more >The work presented in this thesis demonstrates that (1) the neurotrophins NGF and BDNF, which are secreted from OECs, significantly increase OEC proliferation, migration and phagocytosis; (2) OECs in vivo and in culture express the cytokine MIF (shown through immunolabelling, genetic expression and functional assays), and MIF stimulates OEC phagocytosis; (3) MIF is responsible for the segregation of OECs and macrophages in a model of the olfactory nerve as shown by their subsequent mingling upon MIF inhibition. The results here lend evidence that these proteins, which are secreted by OECs, may play a combinatorial role in the olfactory system’s regenerative potential and as such provide direction towards improving the therapeutic potential of OEC transplantation to treat SCI and other nervous system injuries.
View less >
Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
School of Medical Science
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Subject
Spine
Spinal Cord
olfactory ensheathing cells
Macrophage
migration inhibitor factor
MIF