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dc.contributor.advisorEkberg, Jenny A.
dc.contributor.authorWright, Alison Alexandra
dc.date.accessioned2019-12-06T00:08:22Z
dc.date.available2019-12-06T00:08:22Z
dc.date.issued2019-11
dc.identifier.doi10.25904/1912/3038
dc.identifier.urihttp://hdl.handle.net/10072/389563
dc.description.abstractThe work presented in this thesis demonstrates that (1) the neurotrophins NGF and BDNF, which are secreted from OECs, significantly increase OEC proliferation, migration and phagocytosis; (2) OECs in vivo and in culture express the cytokine MIF (shown through immunolabelling, genetic expression and functional assays), and MIF stimulates OEC phagocytosis; (3) MIF is responsible for the segregation of OECs and macrophages in a model of the olfactory nerve as shown by their subsequent mingling upon MIF inhibition. The results here lend evidence that these proteins, which are secreted by OECs, may play a combinatorial role in the olfactory system’s regenerative potential and as such provide direction towards improving the therapeutic potential of OEC transplantation to treat SCI and other nervous system injuries.
dc.languageEnglish
dc.language.isoen
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.subject.keywordsSpine
dc.subject.keywordsSpinal Cord
dc.subject.keywordsolfactory ensheathing cells
dc.subject.keywordsMacrophage
dc.subject.keywordsmigration inhibitor factor
dc.subject.keywordsMIF
dc.titleOlfactory Ensheathing Cell Behaviour and Interactions are Modulated by Secreted Products of OECs
dc.typeGriffith thesis
gro.facultyGriffith Health
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorSt John, James A.
dc.contributor.otheradvisorTodorovic, Michael
dc.contributor.otheradvisorFex-Svenningsen, Asa
gro.thesis.degreelevelThesis (PhD Doctorate)
gro.thesis.degreeprogramDoctor of Philosophy (PhD)
gro.departmentSchool of Medical Science
gro.griffith.authorWright, Alison A.


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