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dc.contributor.authorHo, Yiu Ming
dc.contributor.authorLaycock, Juliet
dc.contributor.authorKirubakaran, Arangan
dc.contributor.authorHussain, Labib
dc.contributor.authorClark, Jeremy
dc.date.accessioned2019-12-10T02:55:50Z
dc.date.available2019-12-10T02:55:50Z
dc.date.issued2019
dc.identifier.issn1445-1433
dc.identifier.doi10.1111/ans.15568
dc.identifier.urihttp://hdl.handle.net/10072/389626
dc.description.abstractBackground: This study aimed to characterize the time‐dependent relationship between serum C‐reactive protein (CRP) and anastomotic integrity in the early post‐operative period and to develop a systematic use of CRP and computed tomography. Methods: Patients aged 18 years or over who had the formation of a left‐sided colonic or a colorectal anastomosis, in Royal Sussex County Hospital, were included. The post‐operative day (POD) CRP cut‐off values were calculated according to receiver operating characteristic analysis to evaluate the sensitivities and specificities of the proposed cut‐off parameters. Results: A total of 125 left‐sided colonic and colorectal anastomoses were recruited and analysed. When comparing to POD1 CRP cut‐off, the calculated CRP ratio cut‐off values of all the rest of PODs (2–5) were highly significant in the laparoscopic group and the overall group (P < 0.001). This statistically significant ratio was also demonstrated in the open group at POD2 (P < 0.0001). Conclusion: CRP and CRP ratios cut‐off values were sensitive to detect an anastomotic leak in the early post‐operative period. The cut‐off values could facilitate the development of systematic use of CRP and computed tomography.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeAustralia
dc.relation.ispartofjournalANZ Journal of Surgery
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode1103
dc.subject.keywordsC-reactive protein
dc.subject.keywordscolonic anastomosis
dc.titleSystematic use of the serum C-reactive protein concentration and computed tomography for the detection of intestinal anastomotic leaks
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationHo, YM; Laycock, J; Kirubakaran, A; Hussain, L; Clark, J, Systematic use of the serum C-reactive protein concentration and computed tomography for the detection of intestinal anastomotic leaks., ANZ Journal of Surgery, 2019
dcterms.dateAccepted2019-10-13
dc.date.updated2019-12-09T04:33:38Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorHo, Yiu Ming


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