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dc.contributor.authorRoyam, Madhav Madurantakam
dc.contributor.authorRamesh, Rithika
dc.contributor.authorShanker, Ritika
dc.contributor.authorSabarimurugan, Shanthi
dc.contributor.authorKumarasamy, Chellan
dc.contributor.authorRamesh, Nachimuthu
dc.contributor.authorGothandam, Kodiveri Muthukalianan
dc.contributor.authorBaxi, Siddharta
dc.contributor.authorGupta, Ajay
dc.contributor.authorKrishnan, Sunil
dc.contributor.authorJayaraj, Rama
dc.date.accessioned2019-12-10T03:00:30Z
dc.date.available2019-12-10T03:00:30Z
dc.date.issued2019
dc.identifier.issn2072-6694
dc.identifier.doi10.3390/cancers11070900
dc.identifier.urihttp://hdl.handle.net/10072/389627
dc.description.abstractBackground: pancreatic cancer (PC) has increasing incidence and mortality in developing countries, and drug resistance is a significant hindrance to the efficacy of successful treatment. The objective of this systematic review and meta-analysis was to evaluate the association between miRNAs and response to chemotherapy in pancreatic cancer patients. Methods: the systematic review and meta-analysis was based on articles collected from a thorough search of PubMed and Science Direct databases for publications spanning from January 2008 to December 2018. The articles were screened via a set of inclusion and exclusion criteria based on the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. Data was extracted, collated and tabulated in MS Excel for further synthesis. Hazard ratio (HR) was selected as the effect size metric to be pooled across studies for the meta-analysis, with the random effects model being applied. Subgroup analysis was also conducted, and the presence of publication bias in the selected studies was assessed. Publication bias of the included studies was quantified. Findings: of the 169 articles screened, 43 studies were included in our systematic review and 13 articles were included in the meta-analysis. Gemcitabine was observed to be the principal drug used in a majority of the studies. A total of 48 miRNAs have been studied, and 18 were observed to have possible contributions to chemoresistance, while 15 were observed to have possible contributions to chemosensitivity. 41 drug-related genetic pathways have been identified, through which the highlighted miRNA may be affecting chemosensitivity/resistance. The pooled HR value for overall survival was 1.603; (95% Confidence Interval (CI) 1.2–2.143; p-value: 0.01), with the subgroup analysis for miR-21 showing HR for resistance of 2.061; 95% CI 1.195–3.556; p-value: 0.09. Interpretation: our results highlight multiple miRNAs that have possible associations with modulation of chemotherapy response in pancreatic cancer patients. Further studies are needed to discover the molecular mechanisms underlying these associations before they can be suggested for use as biomarkers of response to chemotherapeutic interventions in pancreatic cancer.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.publisher.placeSwitzerland
dc.relation.ispartofpagefrom900: 1
dc.relation.ispartofpageto900: 25
dc.relation.ispartofissue7
dc.relation.ispartofjournalCancers
dc.relation.ispartofvolume11
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1112
dc.subject.keywordsREVERSES GEMCITABINE RESISTANCE
dc.subject.keywordsTUMOR-SUPPRESSOR GENE
dc.subject.keywordsUP-REGULATION
dc.subject.keywordsCELL PROLIFERATION
dc.subject.keywordsEXPRESSION
dc.titlemiRNA Predictors of Pancreatic Cancer Chemotherapeutic Response: A Systematic Review and Meta-Analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationRoyam, MM; Ramesh, R; Shanker, R; Sabarimurugan, S; Kumarasamy, C; Ramesh, N; Gothandam, KM; Baxi, S; Gupta, A; Krishnan, S; Jayaraj, R, miRNA Predictors of Pancreatic Cancer Chemotherapeutic Response: A Systematic Review and Meta-Analysis, Cancers, 2019, 11 (7), pp. 900: 1-900: 25
dcterms.dateAccepted2019-06-21
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-12-10T00:58:15Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorBaxi, Siddhartha


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