Immune and microbiome regulation in allergic rhinitis
Author(s)
Primary Supervisor
Cripps, Allan W
Other Supervisors
Cox, Amanda J
West, Nicholas P
Year published
2019-11-12
Metadata
Show full item recordAbstract
Allergic rhinitis (AR) is a common chronic upper respiratory disease where exposure to allergens causes an IgE mediated inflammatory response. AR is estimated to affect between 10-40% of the population worldwide and is responsible for significant economic and medical burden. The primary symptoms of AR include rhinorrhoea, nasal congestion, itchy nose and eyes and sneezing. There is currently no cure for AR and the current treatment options are typically focused on achieving symptom relief. Whilst the symptoms of AR manifest predominately in the upper respiratory tract, the pathophysiology of the disease is complex, and ...
View more >Allergic rhinitis (AR) is a common chronic upper respiratory disease where exposure to allergens causes an IgE mediated inflammatory response. AR is estimated to affect between 10-40% of the population worldwide and is responsible for significant economic and medical burden. The primary symptoms of AR include rhinorrhoea, nasal congestion, itchy nose and eyes and sneezing. There is currently no cure for AR and the current treatment options are typically focused on achieving symptom relief. Whilst the symptoms of AR manifest predominately in the upper respiratory tract, the pathophysiology of the disease is complex, and involves interactions between the mucosal and systemic immune systems. As such, there is an increasing need to better understand the complex immunological mechanisms which underpin the disease. Doing so may lay the foundation for strategies to reduce AR symptoms through modifying the disease process itself or via the development of novel therapies. In a series of six studies, this thesis investigated the pathophysiology and treatment of AR via immune and molecular phenotyping of the gut microbiome, peripheral blood, and nasal mucosa.
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View more >Allergic rhinitis (AR) is a common chronic upper respiratory disease where exposure to allergens causes an IgE mediated inflammatory response. AR is estimated to affect between 10-40% of the population worldwide and is responsible for significant economic and medical burden. The primary symptoms of AR include rhinorrhoea, nasal congestion, itchy nose and eyes and sneezing. There is currently no cure for AR and the current treatment options are typically focused on achieving symptom relief. Whilst the symptoms of AR manifest predominately in the upper respiratory tract, the pathophysiology of the disease is complex, and involves interactions between the mucosal and systemic immune systems. As such, there is an increasing need to better understand the complex immunological mechanisms which underpin the disease. Doing so may lay the foundation for strategies to reduce AR symptoms through modifying the disease process itself or via the development of novel therapies. In a series of six studies, this thesis investigated the pathophysiology and treatment of AR via immune and molecular phenotyping of the gut microbiome, peripheral blood, and nasal mucosa.
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Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
School of Medical Science
Copyright Statement
The author owns the copyright in this thesis, unless stated otherwise.
Subject
Allergic rhinitis
AR
chronic upper respiratory disease
immunological mechanisms