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dc.contributor.authorCorbitt, Matthew
dc.contributor.authorEaton-Fitch, Natalie
dc.contributor.authorStaines, Donald
dc.contributor.authorCabanas, Hélène
dc.contributor.authorMarshall-Gradisnik, Sonya
dc.date.accessioned2019-12-11T23:45:37Z
dc.date.available2019-12-11T23:45:37Z
dc.date.issued2019
dc.identifier.issn1471-2377
dc.identifier.doi10.1186/s12883-019-1433-0
dc.identifier.urihttp://hdl.handle.net/10072/389687
dc.description.abstractBackground: Cytokines in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis/Systemic Exertion Intolerance Disease (CFS/ME/SEID) patients compared with healthy controls have been extensively studied. However, the evidence regarding whether a baseline difference between CFS/ME/SEID patients and the normal population remains unclear. The aim of this study was to conduct a systematic review of the literature regarding cytokines in CFS/ME/SEID and whether there is a significant difference in cytokine levels between this patient group and the normal population. Methods: Pubmed, Scopus, Medline (EBSCOHost), and EMBASE databases were searched to source relevant studies for CFS/ME/SEID. The review included any studies examining cytokines in CFS/ME/SEID patients compared with healthy controls. Results of the literature search were summarised according to aspects of their study design and outcome measures, namely, cytokines. Quality assessment was also completed to summarise the level of evidence available. Results: A total of 16,702 publications were returned using our search terms. After screening of papers according to our inclusion and exclusion criteria, 15 studies were included in the review. All the included studies were observational case control studies. Ten of the studies identified measured serum cytokines in CFS/ME/SEID patients, and four measured cytokines in other physiological fluids of CFS/ME/SEID patients. The overall quality assessment revealed most papers included in this systematic review to be consistent. Conclusions: Despite the availability of moderate quality studies, the findings of this review are inconclusive as to whether cytokines play any definitive role in CFS/ME/SEID, and consequently, they would not serve as reliable biomarkers. Therefore, in light of these results, it is recommended that further efforts toward a diagnostic test and treatment for CFS/ME/SEID continue to be developed in a range of research fields.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofissue1
dc.relation.ispartofjournalBMC Neurology
dc.relation.ispartofvolume19
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1702
dc.subject.keywordsChronic fatigue syndrome
dc.subject.keywordsCytokines
dc.subject.keywordsMyalgic encephalomyelitis
dc.subject.keywordsSystemic exertion intolerance disease
dc.subject.keywordsScience & Technology
dc.titleA systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCorbitt, M; Eaton-Fitch, N; Staines, D; Cabanas, H; Marshall-Gradisnik, S, A systematic review of cytokines in chronic fatigue syndrome/myalgic encephalomyelitis/systemic exertion intolerance disease (CFS/ME/SEID)., BMC Neurology, 2019, 19 (1)
dcterms.dateAccepted2019-08-18
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2019-12-11T23:42:16Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
gro.hasfulltextFull Text
gro.griffith.authorCorbitt, Matthew J.
gro.griffith.authorEaton-Fitch, Natalie R.
gro.griffith.authorStaines, Donald R.
gro.griffith.authorCabanas, Helene
gro.griffith.authorMarshall-Gradisnik, Sonya M.


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