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dc.contributor.authorKuperman, Pora
dc.contributor.authorGranovsky, Yelena
dc.contributor.authorGranot, Michal
dc.contributor.authorBahouth, Hany
dc.contributor.authorFadel, Shiri
dc.contributor.authorHyams, Gila
dc.contributor.authorBen Lulu, Hen
dc.contributor.authorAspis, Osnat
dc.contributor.authorSalame, Rabia
dc.contributor.authorBegal, Julia
dc.contributor.authorHochstein, David
dc.contributor.authorGrunner, Shahar
dc.contributor.authorHonigman, Liat
dc.contributor.authorSterling, Michele
dc.contributor.authoret al.
dc.date.accessioned2019-12-23T04:13:16Z
dc.date.available2019-12-23T04:13:16Z
dc.date.issued2018
dc.identifier.issn0028-3878
dc.identifier.doi10.1212/WNL.0000000000006120
dc.identifier.urihttp://hdl.handle.net/10072/389927
dc.description.abstractOBJECTIVE: To characterize the pain-related somatosensory and psychological presentation of very early acute patients with a mild traumatic brain injury (mTBI). METHODS: Patients with an mTBI participated in a prospective observational study undergoing clinical, psychophysic, and psychological assessment within 72 hours after the accident. Healthy controls underwent similar protocol. RESULTS: One hundred acute patients with an mTBI (age 36 ± 12.5 [SD] years, range 19-67 years, 42 women) and 80 healthy controls (age 43 ± 14.3 years, range 24-74 years, 40 women) participated. Patients with an mTBI demonstrated a pronociceptive psychophysic response in most tests such as less efficient pressure-pain threshold-conditioned pain modulation (0.19 ±0.19±.09 vs. 0.91±.10 kg, p < 0.001) and lower temperature needed to elicit a Pain50 response (44.72 ± 0.26°C vs 46.41 ± 0.30°C, p < 0.001). Their psychophysic findings correlated with clinical pain measures, e.g., Pain50 temperature and mean head (r = -0.21, p = 0.045) and neck (r = -0.26, p = 0.011) pain. The pain-catastrophizing magnification subscale was the only psychological variable to show a difference from the controls, while no significant correlations were found between any psychological measures and the clinical or psychophysic pain measures. CONCLUSIONS: There appears to be a dichotomy between somatosensory and psychological findings in the very early acute post-mTBI stage; while the first is altered and is associated with the clinical picture, the second is unchanged. In the context of the ongoing debate on the pathophysiologic nature of the post-mTBI syndrome, our findings support its "physical" basis, free of mental influence, at least in the short time window after the injury.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofpagefromE931
dc.relation.ispartofpagetoE938
dc.relation.ispartofissue10
dc.relation.ispartofjournalNeurology
dc.relation.ispartofvolume91
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1702
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsClinical Neurology
dc.subject.keywordsCHRONIC WHIPLASH
dc.titlePsychophysic-psychological dichotomy in very early acute mTBI pain: A prospective study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKuperman, P; Granovsky, Y; Granot, M; Bahouth, H; Fadel, S; Hyams, G; Ben Lulu, H; Aspis, O; Salame, R; Begal, J; Hochstein, D; Grunner, S; Honigman, L; Reshef, M; Sprecher, E; Bosak, N; Sterling, M; Yarnitsky, D, Psychophysic-psychological dichotomy in very early acute mTBI pain: A prospective study, Neurology, 2018, 91 (10), pp. E931-E938
dcterms.dateAccepted2018-06-06
dc.date.updated2019-12-23T04:09:45Z
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorSterling, Michele


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