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dc.contributor.authorBaxi, SH
dc.contributor.authorBurmeister, B
dc.contributor.authorHarvey, JA
dc.contributor.authorSmithers, M
dc.contributor.authorThomas, J
dc.date.accessioned2020-01-06T00:00:20Z
dc.date.available2020-01-06T00:00:20Z
dc.date.issued2008
dc.identifier.issn1754-9477
dc.identifier.doi10.1111/j.1440-1673.2008.02023.x
dc.identifier.urihttp://hdl.handle.net/10072/390042
dc.description.abstractTo determine the overall survival and gastrointestinal toxicity for patients treated with salvage definitive chemo-radiotherapy after primary surgery for locoregional relapse of oesophageal carcinoma. A retrospective review of 525 patients who had a resection for oesophageal or oesophagogastric carcinoma at Princess Alexandra Hospital identified 14 patients treated with salvage definitive radiotherapy or chemo-radiotherapy, following localized recurrence of their disease. We analysed the patient and treatment characteristics to determine the median overall survival as the primary end point. Gastrointestinal toxicity was examined to determine if increased toxicity occurred when the stomach was irradiated within the intrathoracic radiotherapy field. The median overall survival for patients treated with curative intent using salvage definitive chemo-radiotherapy was 16 months and the 2-year overall survival is 21%. One patient is in clinical remission more than 5 years after therapy. Age <60 years old and nodal recurrence were favourable prognostic factors. Treatment compliance was 93% with only one patient unable to complete the intended schedule. Fourteen per cent of patients experienced grade 3 or 4 gastrointestinal toxicity. Salvage definitive chemo-radiotherapy should be considered for good performance status patients with oesophageal carcinoma who have a locoregional relapse after primary surgery. The schedule is tolerable with low toxicity and an acceptable median survival.
dc.languageEnglish
dc.language.isoeng
dc.publisherWILEY-BLACKWELL PUBLISHING, INC
dc.relation.ispartofpagefrom583
dc.relation.ispartofpageto587
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of Medical Imaging and Radiation Oncology
dc.relation.ispartofvolume52
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchNursing
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1110
dc.subject.fieldofresearchcode1112
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsRadiology, Nuclear Medicine & Medical Imaging
dc.subject.keywordsrecurrent oesophageal carcinoma
dc.subject.keywordssalvage chemo-radiotherapy
dc.titleSalvage definitive chemo-radiotherapy for locally recurrent oesophageal carcinoma after primary surgery: Retrospective review
dc.typeJournal article
dcterms.bibliographicCitationBaxi, SH; Burmeister, B; Harvey, JA; Smithers, M; Thomas, J, Salvage definitive chemo-radiotherapy for locally recurrent oesophageal carcinoma after primary surgery: Retrospective review, Journal of Medical Imaging and Radiation Oncology, 2008, 52 (6), pp. 583-587
dc.date.updated2020-01-05T23:56:35Z
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2008 Royal Australian and New Zealand College of Radiologists. This is the peer reviewed version of the following article: Salvage definitive chemo‐radiotherapy for locally recurrent oesophageal carcinoma after primary surgery: Retrospective review, Journal of Medical Imaging and Radiation Oncology, Volume 52, Issue 6, Pages 583-587, 2008, which has been published in final form at https://doi.org/10.1111/j.1440-1673.2008.02023.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
gro.hasfulltextFull Text
gro.griffith.authorBaxi, Siddhartha


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