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dc.contributor.authorRosewall, Tara
dc.contributor.authorBayley, Andrew J
dc.contributor.authorChung, Peter
dc.contributor.authorLe, Lisa W
dc.contributor.authorXie, Jason
dc.contributor.authorBaxi, Siddhartha
dc.contributor.authorCatton, Charles N
dc.contributor.authorCurrie, Geoffrey
dc.contributor.authorWheat, Janelle
dc.contributor.authorMilosevic, Michael
dc.description.abstractPURPOSE: To quantify the effect of delineation method on bladder DVH, observer variability (OV) and contouring time for prostate IMRT plans. MATERIALS AND METHODS: Planning CT scans and IMRT plans of 30 prostate cancer patients were anonymized. For 20 patients, 1 observer delineated the bladder using 9 methods. The effect of delineation method on the DVH curve, discrete dose levels and delineation time was quantified. For the 10 remaining CTs, 6 observers delineated bladder wall using 4 methods. Observer-based volume variation and intraclass correlation coefficient (ICC) were used to describe the dosimetric effects of OV. RESULTS: Manual delineation of the bladder wall (BW_m) was significantly slower than any other method (mean: 20 min vs. ≤ 13 min) and the dosimetric effect of OV was significantly larger (V70 Gy ICC: 0.78 vs. 0.98). Only volumes created using a 2.5mm contraction from the outer surface, and a method providing a consistent wall volume, showed no notable dosimetric differences from BW_m in both absolute and relative volume. CONCLUSIONS: Automatic contractions from the outer surface provide quicker, more reproducible and reasonably accurate substitutes for BW_m. The widespread use of automatic contractions to create a bladder wall volume would assist in the consistent application of IMRT dose constraints and the interpretation of reported dose.
dc.relation.ispartofjournalRadiotherapy and Oncology
dc.subject.fieldofresearchOther Physical Sciences
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsRadiology, Nuclear Medicine & Medical Imaging
dc.subject.keywordsOrgan at risk
dc.titleThe effect of delineation method and observer variability on bladder dose-volume histograms for prostate intensity modulated radiotherapy
dc.typeJournal article
dcterms.bibliographicCitationRosewall, T; Bayley, AJ; Chung, P; Le, LW; Xie, J; Baxi, S; Catton, CN; Currie, G; Wheat, J; Milosevic, M, The effect of delineation method and observer variability on bladder dose-volume histograms for prostate intensity modulated radiotherapy, Radiotherapy and Oncology, 2011, 101 (3), pp. 479-485
gro.hasfulltextNo Full Text
gro.griffith.authorBaxi, Siddhartha

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