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dc.contributor.authorGogna, Nirdosh Kumar
dc.contributor.authorBaxi, Siddhartha
dc.contributor.authorHickey, Brigid
dc.contributor.authorBaumann, Kathryn
dc.contributor.authorBurmeister, Elizabeth
dc.contributor.authorHolt, Tanya
dc.date.accessioned2020-01-06T04:32:27Z
dc.date.available2020-01-06T04:32:27Z
dc.date.issued2012
dc.identifier.issn0360-3016
dc.identifier.doi10.1016/j.ijrobp.2011.12.028
dc.identifier.urihttp://hdl.handle.net/10072/390054
dc.description.abstractPURPOSE: Local progression, in patients with hormone-refractory prostate cancer, often causes significant morbidity. Pelvic radiotherapy (RT) provides effective palliation in this setting, with most published studies supporting the use of high-dose regimens. The aim of the present study was to examine the role of split-course hypofractionated RT used at our institution in treating this group of patients. METHODS AND MATERIALS: A total of 34 men with locoregionally progressive hormone-refractory prostate cancer, treated with a split course of pelvic RT (45-60 Gy in 18-24 fractions) between 2000 and 2008 were analyzed. The primary endpoints were the response rate and actuarial locoregional progression-free survival. Secondary endpoints included overall survival, compliance, and acute and late toxicity. RESULTS: The median age was 71 years (range, 53-88). Treatment resulted in an overall initial response rate of 91%, a median locoregional progression-free survival of 43 months, and median overall survival of 28 months. Compliance was excellent and no significant late toxicity was reported. CONCLUSIONS: The split course pelvic RT described has an acceptable toxicity profile, is effective, and compares well with other high-dose palliative regimens that have been previously reported.
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefromE205
dc.relation.ispartofpagetoE211
dc.relation.ispartofissue2
dc.relation.ispartofjournalInternational Journal of Radiation Oncology, Biology, Physics
dc.relation.ispartofvolume83
dc.subject.fieldofresearchOther physical sciences
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode5199
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3211
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsRadiology, Nuclear Medicine & Medical Imaging
dc.subject.keywordsHormone-refractory prostate cancer
dc.titleSplit-Course, High-Dose Palliative Pelvic Radiotherapy for Locally Progressive Hormone-Refractory Prostate Cancer
dc.typeJournal article
dcterms.bibliographicCitationGogna, NK; Baxi, S; Hickey, B; Baumann, K; Burmeister, E; Holt, T, Split-Course, High-Dose Palliative Pelvic Radiotherapy for Locally Progressive Hormone-Refractory Prostate Cancer, International Journal of Radiation Oncology, Biology, Physics, 2012, 83 (2), pp. E205-E211
dcterms.dateAccepted2011-12-06
dc.date.updated2020-01-06T04:30:53Z
gro.hasfulltextNo Full Text
gro.griffith.authorBaxi, Siddhartha


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