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dc.contributor.authorCanellas, JVDS
dc.contributor.authorda Costa, RC
dc.contributor.authorBreves, RC
dc.contributor.authorde Oliveira, GP
dc.contributor.authorFigueredo, CMDS
dc.contributor.authorFischer, RG
dc.contributor.authorThole, AA
dc.contributor.authorMedeiros, PJDA
dc.contributor.authorRitto, FG
dc.date.accessioned2020-01-13T01:51:23Z
dc.date.available2020-01-13T01:51:23Z
dc.date.issued2019
dc.identifier.issn1010-5182
dc.identifier.doi10.1016/j.jcms.2019.11.006
dc.identifier.urihttp://hdl.handle.net/10072/390135
dc.description.abstractThe use of platelet concentrate in alveolar ridge preservation has been broadly studied. However, no randomized clinical trials with histomorphometric analysis and low risk of bias are available in the literature. We conducted a prospective, single-blind, parallel, randomized, controlled clinical trial to evaluate the efficacy of leukocyte- and platelet-rich fibrin (L-PRF) in socket preservation after tooth extraction. Additionally, the effect of L-PRF on bone formation was analyzed histologically using bone biopsy specimens obtained during implant placement. A total of 48 subjects who underwent a non-molar tooth extraction were randomly assigned to the L-PRF group (n = 24) or the control group (n = 24). Cone-beam computed tomographies were performed immediately after tooth extraction and at 3 months after tooth extraction, prior to implant surgery. A significant difference in bone resorption was registered 1 mm below the crest: 0.93 ± 0.9 mm for the L-PRF group and 2.27 ± 1.2 mm for the control group (p = 0.0001). Histomorphometric analysis showed a higher percentage of new bone formation in the L-PRF group compared with the control group. The values were 55.96 ± 11.97% and 39.69 ± 11.13%, respectively (p = 0.00001). These findings indicate that the administration of L-PRF should always be considered when socket preservation is planned (Clinicaltrials.gov NCT03408418).
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofjournalJournal of Cranio-Maxillofacial Surgery
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1105
dc.subject.keywordsAlveolar preservation
dc.subject.keywordsBiopsy
dc.subject.keywordsBone healing
dc.subject.keywordsHistomorphometry
dc.subject.keywordsPlatelet-rich fibrin
dc.titleTomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: A randomized, single-blind, controlled clinical trial
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCanellas, JVDS; da Costa, RC; Breves, RC; de Oliveira, GP; Figueredo, CMDS; Fischer, RG; Thole, AA; Medeiros, PJDA; Ritto, FG, Tomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: A randomized, single-blind, controlled clinical trial, Journal of Cranio-Maxillofacial Surgery, 2019
dcterms.dateAccepted2019-11-18
dc.date.updated2020-01-10T03:55:24Z
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version
gro.hasfulltextNo Full Text
gro.griffith.authorda Silva Figueredo, Carlos Marcelo


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