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dc.contributor.authorRalph, Stephen
dc.contributor.authorFerguson, Samantha
dc.coverage.spatialClinical Trials Unit, G40 Health Centre, Griffith University Parklands Avenue, Southport.en_US
dc.coverage.temporal2018-11 to 2019-05en_US
dc.description.abstractBackground: Previous open-label studies showed that chronic post-stroke pain could be abated by treatment with perispinal etanercept, although these benefits were questioned. A randomized double-blind placebo controlled clinical trial was conducted to test perispinal etanercept for chronic post-stroke pain. Research design and methods: Participants received two treatments, either perispinal etanercept (active) or saline (control). Primary outcomes were the differences in daily pain levels between groups analyzed by SPSS. Results: On the 0–100 points visual analog scale, perispinal etanercept reduced mean levels for worst and average daily pain from baseline after two treatments by 19.5 – 24 points (p < 0.05), and pain alleviation was maintained in the etanercept group, with no significant change in the control group. Thirty percent of etanercept participants had near complete pain abatement after first treatment. Goniometry of the paretic arm showed improved mean shoulder rotation by 55 degrees in active forward flexion for the etanercept group (p = 0.003) only. Conclusions: Perispinal etanercept can provide significant and ongoing benefits for the chronic poststroke management of pain and greater shoulder flexion by the paretic arm. Effects are rapid and highly significant, supporting direct action on brain function. Trial registration: ACTRN12615001377527 and Universal Trial Number U1111-1174-3242.en_US
dc.format.mediumInstrument measurements in .xlsxen_US
dc.publisherGriffith Universityen_US
dc.subject.fieldofresearchCentral Nervous Systemen_US
dc.subject.fieldofresearchNeurology and Neuromuscular Diseasesen_US
dc.subject.keywordsClinical trialen_US
dc.subject.keywordsperispinal etanercepten_US
dc.subject.keywordsreduced post-stroke painen_US
dc.subject.keywordsincreased flexionen_US
dc.titlePhase I/II parallel double-blind randomized controlled clinical trial of perispinal etanercept for chronic strokeen_US
dcterms.rightsHolderAssociate Professor Stephen Ralphen_US
gro.facultySchool of Medical Scienceen_US
gro.description.notepublicDataset supporting publication: Phase I/II parallel double-blind randomized controlled clinical trial of perispinal etanercept for chronic stroke: improved mobility and pain alleviation. Ralph SJ, Weissenberger A, Bonev V, King LD, Bonham MD, Ferguson S, Smith AD, Goodman-Jones AA, Espinet AJ. Expert Opin Investig Drugs. 2020 Jan 3:1-16. doi: 10.1080/13543784.2020.1709822. [Epub ahead of print] PMID: 31899977en_US
gro.rights.copyrightRestricted access and viewing. Investigators must request access for citation or collaboration after completing agreement. No restrictions for how people with access can reuse the data following approved access. Requests via mediated request form.en_US
gro.hasfulltextNo Full Text
dc.rights.accessRightsMediated access requests via link provided.en_US
gro.griffith.authorRalph, Stephen J.
gro.griffith.authorFerguson, Samantha

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