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  • Nosocomial infection prevalence in patients undergoing extracorporeal membrane oxygenation (ECMO): protocol for a point prevalence study across Australia and New Zealand

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    Author(s)
    Corley, Amanda
    Lye, India
    Lavana, Jayshree D
    Ahuja, Abhilasha
    Anstey, Chris M
    Jarrett, Paul
    Haisz, Emma
    Parke, Rachael
    Pellegrino, Vincent
    Buscher, Hergen
    Fraser, John F
    Griffith University Author(s)
    Corley, Amanda
    Anstey, Chris
    Year published
    2019
    Metadata
    Show full item record
    Abstract
    Introduction: Extracorporeal membrane oxygenation (ECMO) provides cardiac and/or respiratory support when other therapies fail. Nosocomial infection is reported in up to 64% of patients receiving ECMO and increases morbidity and mortality. These patients are at high risk of infection due, in part, to the multiple invasive devices required in their management, the largest being the cannulae through which ECMO is delivered. Prevalence of nosocomial infection in ECMO patients, including ECMO cannula-related infection, is not well described across Australia and New Zealand. Methods and analysis: This is a prospective, observational ...
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    Introduction: Extracorporeal membrane oxygenation (ECMO) provides cardiac and/or respiratory support when other therapies fail. Nosocomial infection is reported in up to 64% of patients receiving ECMO and increases morbidity and mortality. These patients are at high risk of infection due, in part, to the multiple invasive devices required in their management, the largest being the cannulae through which ECMO is delivered. Prevalence of nosocomial infection in ECMO patients, including ECMO cannula-related infection, is not well described across Australia and New Zealand. Methods and analysis: This is a prospective, observational point prevalence study of 12 months duration conducted at 11 ECMO centres across Australia and New Zealand. Data will be collected for every patient receiving ECMO during 12 predetermined data collection weeks. The primary outcome is the prevalence of laboratory-confirmed bloodstream infection, and suspected or probable nosocomial infections; and the secondary outcomes include describing ECMO cannula dressing and securement practices, and adherence to local dressing and securement guidelines. Data collection will be finalised by March 2019. Ethics and dissemination: Relevant ethical and governance approvals have been received. Study results will describe the prevalence of suspected and confirmed nosocomial infection in adult, paediatric and neonatal patients receiving ECMO across Australia and New Zealand. It is expected that the results will be hypothesis generating and lead to interventional trials aimed at reducing the high infection rates seen in this cohort. Results will be published in peer-reviewed journals and presented at relevant conferences.
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    Journal Title
    BMJ Open
    Volume
    9
    Issue
    7
    DOI
    https://doi.org/10.1136/bmjopen-2019-029293
    Copyright Statement
    © The Author(s) 2019. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
    Subject
    Clinical sciences
    Health services and systems
    Public health
    Other health sciences
    Science & Technology
    Life Sciences & Biomedicine
    Medicine, General & Internal
    General & Internal Medicine
    RANDOMIZED CONTROLLED-TRIAL
    Publication URI
    http://hdl.handle.net/10072/390293
    Collection
    • Journal articles

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